| 1 | Sat 19 Aug | 182-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-2 RB Leipzig | German Bundesliga |
| 2 | Sat 16 Sep | 183-0 v FC AugsburgRB Leipzig 3-0 FC Augsburg | German Bundesliga |
| 3 | Sat 23 Sep | 181-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-1 RB Leipzig | German Bundesliga |
| 4 | Sat 30 Sep | 182-2 v Bayern MunichRB Leipzig 2-2 Bayern Munich | German Bundesliga |
| 5 | Sat 7 Oct | 180-0 v VfL BochumRB Leipzig 0-0 VfL Bochum | German Bundesliga |
| 6 | Sat 28 Oct | 186-0 v 1 FC KölnRB Leipzig 6-0 1 FC Köln | German Bundesliga |
| 7 | Tue 7 Nov | 182-1 v Red Star BelgradeRed Star Belgrade 1-2 RB Leipzig | UEFA Champions League Group G |
| 8 | Sat 25 Nov | 181-2 v VfL WolfsburgVfL Wolfsburg 2-1 RB Leipzig | German Bundesliga |
| 9 | Tue 28 Nov | 182-3 v Manchester CityManchester City 3-2 RB Leipzig | UEFA Champions League Group G |
| 10 | Wed 13 Dec | 182-1 v Young BoysRB Leipzig 2-1 Young Boys | UEFA Champions League Group G |
| 11 | Sat 16 Dec | 183-1 v 1899 HoffenheimRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
| 12 | Tue 19 Dec | 181-1 v Werder BremenWerder Bremen 1-1 RB Leipzig | German Bundesliga |
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