| 1 | Sat 19 Aug | 442-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-2 RB Leipzig | German Bundesliga |
| 2 | Fri 25 Aug | 445-1 v VfB StuttgartRB Leipzig 5-1 VfB Stuttgart | German Bundesliga |
| 3 | Sun 3 Sep | 443-0 v 1 FC Union Berlin1 FC Union Berlin 0-3 RB Leipzig | German Bundesliga |
| 4 | Sat 16 Sep | 443-0 v FC AugsburgRB Leipzig 3-0 FC Augsburg | German Bundesliga |
| 5 | Tue 19 Sep | 44 3-1 v Young BoysYoung Boys 1-3 RB Leipzig | UEFA Champions League Group G |
| 6 | Sat 23 Sep | 441-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-1 RB Leipzig | German Bundesliga |
| 7 | Sat 30 Sep | 442-2 v Bayern MunichRB Leipzig 2-2 Bayern Munich | German Bundesliga |
| 8 | Sat 7 Oct | 440-0 v VfL BochumRB Leipzig 0-0 VfL Bochum | German Bundesliga |
| 9 | Sat 21 Oct | 44 3-1 v Darmstadt 98Darmstadt 98 1-3 RB Leipzig | German Bundesliga |
| 10 | Wed 25 Oct | 443-1 v Red Star BelgradeRB Leipzig 3-1 Red Star Belgrade | UEFA Champions League Group G |
| 11 | Sat 4 Nov | 440-2 v Mainz 05Mainz 05 2-0 RB Leipzig | German Bundesliga |
| 12 | Tue 7 Nov | 442-1 v Red Star BelgradeRed Star Belgrade 1-2 RB Leipzig | UEFA Champions League Group G |
| 13 | Sun 12 Nov | 443-1 v SC FreiburgRB Leipzig 3-1 SC Freiburg | German Bundesliga |
| 14 | Tue 28 Nov | 442-3 v Manchester CityManchester City 3-2 RB Leipzig | UEFA Champions League Group G |
| 15 | Sat 9 Dec | 443-2 v Borussia DortmundBorussia Dortmund 2-3 RB Leipzig | German Bundesliga |
| 16 | Wed 13 Dec | 442-1 v Young BoysRB Leipzig 2-1 Young Boys | UEFA Champions League Group G |
| 17 | Sat 16 Dec | 443-1 v 1899 HoffenheimRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
| 18 | Tue 19 Dec | 44 1-1 v Werder BremenWerder Bremen 1-1 RB Leipzig | German Bundesliga |
| 19 | Sat 13 Jan | 440-1 v Eintracht FrankfurtRB Leipzig 0-1 Eintracht Frankfurt | German Bundesliga |
| 20 | Sat 20 Jan | 442-3 v Bayer 04 LeverkusenRB Leipzig 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 21 | Sat 27 Jan | 442-5 v VfB StuttgartVfB Stuttgart 5-2 RB Leipzig | German Bundesliga |
| 22 | Sun 4 Feb | 44 2-0 v 1 FC Union BerlinRB Leipzig 2-0 1 FC Union Berlin | German Bundesliga |
| 23 | Sat 10 Feb | 442-2 v FC AugsburgFC Augsburg 2-2 RB Leipzig | German Bundesliga |
| 24 | Tue 13 Feb | 440-1 v Real MadridRB Leipzig 0-1 Real Madrid | UEFA Champions League Round of 16 |
| 25 | Sat 24 Feb | 441-2 v Bayern MunichBayern Munich 2-1 RB Leipzig | German Bundesliga |
| 26 | Wed 6 Mar | 441-1 v Real MadridReal Madrid 1-1 RB Leipzig | UEFA Champions League Round of 16 |
| 27 | Sat 9 Mar | 442-0 v Darmstadt 98RB Leipzig 2-0 Darmstadt 98 | German Bundesliga |
| 28 | Fri 15 Mar | 445-1 v 1 FC Köln1 FC Köln 1-5 RB Leipzig | German Bundesliga |
| 29 | Sat 30 Mar | 440-0 v Mainz 05RB Leipzig 0-0 Mainz 05 | German Bundesliga |
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