| 1 | Sat 19 Aug | 222-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-2 RB Leipzig | German Bundesliga |
| 2 | Fri 25 Aug | 225-1 v VfB StuttgartRB Leipzig 5-1 VfB Stuttgart | German Bundesliga |
| 3 | Sun 3 Sep | 223-0 v 1 FC Union Berlin1 FC Union Berlin 0-3 RB Leipzig | German Bundesliga |
| 4 | Sat 16 Sep | 223-0 v FC AugsburgRB Leipzig 3-0 FC Augsburg | German Bundesliga |
| 5 | Tue 19 Sep | 223-1 v Young BoysYoung Boys 1-3 RB Leipzig | UEFA Champions League Group G |
| 6 | Sat 23 Sep | 22 1-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-1 RB Leipzig | German Bundesliga |
| 7 | Sat 30 Sep | 222-2 v Bayern MunichRB Leipzig 2-2 Bayern Munich | German Bundesliga |
| 8 | Wed 4 Oct | 22 1-3 v Manchester CityRB Leipzig 1-3 Manchester City | UEFA Champions League Group G |
| 9 | Sat 7 Oct | 220-0 v VfL BochumRB Leipzig 0-0 VfL Bochum | German Bundesliga |
| 10 | Sat 21 Oct | 22 3-1 v Darmstadt 98Darmstadt 98 1-3 RB Leipzig | German Bundesliga |
| 11 | Wed 25 Oct | 223-1 v Red Star BelgradeRB Leipzig 3-1 Red Star Belgrade | UEFA Champions League Group G |
| 12 | Sat 28 Oct | 226-0 v 1 FC KölnRB Leipzig 6-0 1 FC Köln | German Bundesliga |
| 13 | Sat 4 Nov | 220-2 v Mainz 05Mainz 05 2-0 RB Leipzig | German Bundesliga |
| 14 | Tue 7 Nov | 222-1 v Red Star BelgradeRed Star Belgrade 1-2 RB Leipzig | UEFA Champions League Group G |
| 15 | Sun 12 Nov | 223-1 v SC FreiburgRB Leipzig 3-1 SC Freiburg | German Bundesliga |
| 16 | Sat 25 Nov | 221-2 v VfL WolfsburgVfL Wolfsburg 2-1 RB Leipzig | German Bundesliga |
| 17 | Tue 28 Nov | 222-3 v Manchester CityManchester City 3-2 RB Leipzig | UEFA Champions League Group G |
| 18 | Sat 2 Dec | 222-1 v 1 FC HeidenheimRB Leipzig 2-1 1 FC Heidenheim | German Bundesliga |
| 19 | Sat 9 Dec | 223-2 v Borussia DortmundBorussia Dortmund 2-3 RB Leipzig | German Bundesliga |
| 20 | Sat 16 Dec | 223-1 v 1899 HoffenheimRB Leipzig 3-1 1899 Hoffenheim | German Bundesliga |
| 21 | Tue 19 Dec | 221-1 v Werder BremenWerder Bremen 1-1 RB Leipzig | German Bundesliga |
| 22 | Sat 13 Jan | 220-1 v Eintracht FrankfurtRB Leipzig 0-1 Eintracht Frankfurt | German Bundesliga |
| 23 | Sat 20 Jan | 222-3 v Bayer 04 LeverkusenRB Leipzig 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 24 | Sat 27 Jan | 22 2-5 v VfB StuttgartVfB Stuttgart 5-2 RB Leipzig | German Bundesliga |
| 25 | Sun 4 Feb | 222-0 v 1 FC Union BerlinRB Leipzig 2-0 1 FC Union Berlin | German Bundesliga |
| 26 | Sat 10 Feb | 22 2-2 v FC AugsburgFC Augsburg 2-2 RB Leipzig | German Bundesliga |
| 27 | Tue 13 Feb | 220-1 v Real MadridRB Leipzig 0-1 Real Madrid | UEFA Champions League Round of 16 |
| 28 | Sat 17 Feb | 222-0 v Borussia MönchengladbachRB Leipzig 2-0 Borussia Mönchengladbach | German Bundesliga |
| 29 | Sat 24 Feb | 221-2 v Bayern MunichBayern Munich 2-1 RB Leipzig | German Bundesliga |
| 30 | Sat 2 Mar | 224-1 v VfL BochumVfL Bochum 1-4 RB Leipzig | German Bundesliga |
| 31 | Wed 6 Mar | 22 1-1 v Real MadridReal Madrid 1-1 RB Leipzig | UEFA Champions League Round of 16 |
| 32 | Sat 9 Mar | 222-0 v Darmstadt 98RB Leipzig 2-0 Darmstadt 98 | German Bundesliga |
| 33 | Fri 15 Mar | 225-1 v 1 FC Köln1 FC Köln 1-5 RB Leipzig | German Bundesliga |
| 34 | Sat 30 Mar | 220-0 v Mainz 05RB Leipzig 0-0 Mainz 05 | German Bundesliga |
| 35 | Sat 6 Apr | 22 4-1 v SC FreiburgSC Freiburg 1-4 RB Leipzig | German Bundesliga |
| 36 | Sat 20 Apr | 222-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 RB Leipzig | German Bundesliga |
| 37 | Sat 27 Apr | 224-1 v Borussia DortmundRB Leipzig 4-1 Borussia Dortmund | German Bundesliga |
| 38 | Fri 3 May | 22 1-1 v 1899 Hoffenheim1899 Hoffenheim 1-1 RB Leipzig | German Bundesliga |
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