| 1 | Sat 19 Aug | 42-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-2 RB Leipzig | German Bundesliga |
| 2 | Fri 25 Aug | 45-1 v VfB StuttgartRB Leipzig 5-1 VfB Stuttgart | German Bundesliga |
| 3 | Sun 3 Sep | 43-0 v 1 FC Union Berlin1 FC Union Berlin 0-3 RB Leipzig | German Bundesliga |
| 4 | Sat 27 Jan | 42-5 v VfB StuttgartVfB Stuttgart 5-2 RB Leipzig | German Bundesliga |
| 5 | Sun 4 Feb | 42-0 v 1 FC Union BerlinRB Leipzig 2-0 1 FC Union Berlin | German Bundesliga |
| 6 | Sat 10 Feb | 42-2 v FC AugsburgFC Augsburg 2-2 RB Leipzig | German Bundesliga |
| 7 | Tue 13 Feb | 40-1 v Real MadridRB Leipzig 0-1 Real Madrid | UEFA Champions League Round of 16 |
| 8 | Sat 17 Feb | 42-0 v Borussia MönchengladbachRB Leipzig 2-0 Borussia Mönchengladbach | German Bundesliga |
| 9 | Sat 24 Feb | 4 1-2 v Bayern MunichBayern Munich 2-1 RB Leipzig | German Bundesliga |
| 10 | Sat 2 Mar | 44-1 v VfL BochumVfL Bochum 1-4 RB Leipzig | German Bundesliga |
| 11 | Wed 6 Mar | 4 1-1 v Real MadridReal Madrid 1-1 RB Leipzig | UEFA Champions League Round of 16 |
| 12 | Sat 9 Mar | 42-0 v Darmstadt 98RB Leipzig 2-0 Darmstadt 98 | German Bundesliga |
| 13 | Fri 15 Mar | 45-1 v 1 FC Köln1 FC Köln 1-5 RB Leipzig | German Bundesliga |
| 14 | Sat 30 Mar | 40-0 v Mainz 05RB Leipzig 0-0 Mainz 05 | German Bundesliga |
| 15 | Sat 6 Apr | 4 4-1 v SC FreiburgSC Freiburg 1-4 RB Leipzig | German Bundesliga |
| 16 | Sat 13 Apr | 43-0 v VfL WolfsburgRB Leipzig 3-0 VfL Wolfsburg | German Bundesliga |
| 17 | Sat 20 Apr | 42-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 RB Leipzig | German Bundesliga |
| 18 | Sat 27 Apr | 44-1 v Borussia DortmundRB Leipzig 4-1 Borussia Dortmund | German Bundesliga |
| 19 | Fri 3 May | 41-1 v 1899 Hoffenheim1899 Hoffenheim 1-1 RB Leipzig | German Bundesliga |
| 20 | Sat 11 May | 41-1 v Werder BremenRB Leipzig 1-1 Werder Bremen | German Bundesliga |
| 21 | Sat 18 May | 42-2 v Eintracht FrankfurtEintracht Frankfurt 2-2 RB Leipzig | German Bundesliga |
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