| 1 | Sat 19 Aug | 13 2-3 v Bayer 04 LeverkusenBayer 04 Leverkusen 3-2 RB Leipzig | German Bundesliga |
| 2 | Sat 23 Sep | 131-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-1 RB Leipzig | German Bundesliga |
| 3 | Sat 30 Sep | 132-2 v Bayern MunichRB Leipzig 2-2 Bayern Munich | German Bundesliga |
| 4 | Wed 4 Oct | 131-3 v Manchester CityRB Leipzig 1-3 Manchester City | UEFA Champions League Group G |
| 5 | Sat 21 Oct | 133-1 v Darmstadt 98Darmstadt 98 1-3 RB Leipzig | German Bundesliga |
| 6 | Tue 7 Nov | 132-1 v Red Star BelgradeRed Star Belgrade 1-2 RB Leipzig | UEFA Champions League Group G |
| 7 | Sat 25 Nov | 131-2 v VfL WolfsburgVfL Wolfsburg 2-1 RB Leipzig | German Bundesliga |
| 8 | Tue 28 Nov | 132-3 v Manchester CityManchester City 3-2 RB Leipzig | UEFA Champions League Group G |
| 9 | Wed 13 Dec | 132-1 v Young BoysRB Leipzig 2-1 Young Boys | UEFA Champions League Group G |
| 10 | Tue 19 Dec | 131-1 v Werder BremenWerder Bremen 1-1 RB Leipzig | German Bundesliga |
| 11 | Sat 20 Jan | 132-3 v Bayer 04 LeverkusenRB Leipzig 2-3 Bayer 04 Leverkusen | German Bundesliga |
| 12 | Sat 27 Jan | 132-5 v VfB StuttgartVfB Stuttgart 5-2 RB Leipzig | German Bundesliga |
| 13 | Sun 4 Feb | 132-0 v 1 FC Union BerlinRB Leipzig 2-0 1 FC Union Berlin | German Bundesliga |
| 14 | Sat 10 Feb | 132-2 v FC AugsburgFC Augsburg 2-2 RB Leipzig | German Bundesliga |
| 15 | Sat 17 Feb | 132-0 v Borussia MönchengladbachRB Leipzig 2-0 Borussia Mönchengladbach | German Bundesliga |
| 16 | Sat 2 Mar | 134-1 v VfL BochumVfL Bochum 1-4 RB Leipzig | German Bundesliga |
| 17 | Sat 9 Mar | 132-0 v Darmstadt 98RB Leipzig 2-0 Darmstadt 98 | German Bundesliga |
| 18 | Sat 30 Mar | 130-0 v Mainz 05RB Leipzig 0-0 Mainz 05 | German Bundesliga |
| 19 | Sat 6 Apr | 134-1 v SC FreiburgSC Freiburg 1-4 RB Leipzig | German Bundesliga |
| 20 | Sat 13 Apr | 133-0 v VfL WolfsburgRB Leipzig 3-0 VfL Wolfsburg | German Bundesliga |
| 21 | Sat 20 Apr | 132-1 v 1 FC Heidenheim1 FC Heidenheim 1-2 RB Leipzig | German Bundesliga |
| 22 | Sat 27 Apr | 134-1 v Borussia DortmundRB Leipzig 4-1 Borussia Dortmund | German Bundesliga |
| 23 | Fri 3 May | 131-1 v 1899 Hoffenheim1899 Hoffenheim 1-1 RB Leipzig | German Bundesliga |
| 24 | Sat 11 May | 131-1 v Werder BremenRB Leipzig 1-1 Werder Bremen | German Bundesliga |
| 25 | Sat 18 May | 132-2 v Eintracht FrankfurtEintracht Frankfurt 2-2 RB Leipzig | German Bundesliga |
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