| 1 | Mon 13 Sep 2021 | 192-1 v GranadaGranada 1-2 Real Betis | Spanish La Liga |
| 2 | Sun 19 Sep 2021 | 192-2 v EspanyolReal Betis 2-2 Espanyol | Spanish La Liga |
| 3 | Sun 26 Sep 2021 | 192-0 v GetafeReal Betis 2-0 Getafe | Spanish La Liga |
| 4 | Sun 3 Oct 2021 | 190-2 v VillarrealVillarreal 2-0 Real Betis | Spanish La Liga |
| 5 | Mon 18 Oct 2021 | 191-0 v AlavésAlavés 0-1 Real Betis | Spanish La Liga |
| 6 | Sun 24 Oct 2021 | 193-2 v Rayo VallecanoReal Betis 3-2 Rayo Vallecano | Spanish La Liga |
| 7 | Thu 4 Nov 2021 | 190-4 v Bayer 04 LeverkusenBayer 04 Leverkusen 4-0 Real Betis | UEFA Europa League Group G |
| 8 | Sun 7 Nov 2021 | 190-2 v SevillaReal Betis 0-2 Sevilla | Spanish La Liga |
| 9 | Sun 21 Nov 2021 | 19 3-0 v ElcheElche 0-3 Real Betis | Spanish La Liga |
| 10 | Thu 25 Nov 2021 | 192-0 v Ferencvárosi TCReal Betis 2-0 Ferencvárosi TC | UEFA Europa League Group G |
| 11 | Sat 4 Dec 2021 | 191-0 v BarcelonaBarcelona 0-1 Real Betis | Spanish La Liga |
| 12 | Sun 12 Dec 2021 | 194-0 v Real SociedadReal Betis 4-0 Real Sociedad | Spanish La Liga |
| 13 | Sun 19 Dec 2021 | 192-3 v Athletic BilbaoAthletic Bilbao 3-2 Real Betis | Spanish La Liga |
| 14 | Sun 2 Jan 2022 | 190-2 v Celta VigoReal Betis 0-2 Celta Vigo | Spanish La Liga |
| 15 | Sun 9 Jan 2022 | 191-1 v Rayo VallecanoRayo Vallecano 1-1 Real Betis | Spanish La Liga |
| 16 | Tue 18 Jan 2022 | 194-0 v AlavésReal Betis 4-0 Alavés | Spanish La Liga |
| 17 | Sun 6 Feb 2022 | 190-2 v VillarrealReal Betis 0-2 Villarreal | Spanish La Liga |
| 18 | Sun 13 Feb 2022 | 19 4-2 v LevanteLevante 2-4 Real Betis | Spanish La Liga |
| 19 | Thu 17 Feb 2022 | 193-2 v Zenit St PetersburgZenit St Petersburg 2-3 Real Betis | UEFA Europa League Round of 32 |
| 20 | Sun 20 Feb 2022 | 19 2-1 v MallorcaReal Betis 2-1 Mallorca | Spanish La Liga |
| 21 | Thu 24 Feb 2022 | 190-0 v Zenit St PetersburgReal Betis 0-0 Zenit St Petersburg | UEFA Europa League Round of 32 |
| 22 | Sun 27 Feb 2022 | 191-2 v SevillaSevilla 2-1 Real Betis | Spanish La Liga |
| 23 | Sun 20 Mar 2022 | 190-0 v Celta VigoCelta Vigo 0-0 Real Betis | Spanish La Liga |
| 24 | Sun 3 Apr 2022 | 194-1 v OsasunaReal Betis 4-1 Osasuna | Spanish La Liga |
| 25 | Sat 9 Apr 2022 | 192-1 v CádizCádiz 1-2 Real Betis | Spanish La Liga |
| 26 | Fri 15 Apr 2022 | 190-0 v Real SociedadReal Sociedad 0-0 Real Betis | Spanish La Liga |
| 27 | Sun 15 May 2022 | 192-0 v GranadaReal Betis 2-0 Granada | Spanish La Liga |
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