| 1 | Sun 13 Aug | 62-1 v VillarrealVillarreal 1-2 Real Betis | Spanish La Liga |
| 2 | Sun 20 Aug | 60-0 v Atlético MadridReal Betis 0-0 Atlético Madrid | Spanish La Liga |
| 3 | Sun 27 Aug | 62-4 v Athletic BilbaoAthletic Bilbao 4-2 Real Betis | Spanish La Liga |
| 4 | Sat 2 Sep | 61-0 v Rayo VallecanoReal Betis 1-0 Rayo Vallecano | Spanish La Liga |
| 5 | Thu 21 Sep | 6 0-1 v RangersRangers 1-0 Real Betis | UEFA Europa League Group C |
| 6 | Sun 24 Sep | 61-1 v CádizReal Betis 1-1 Cádiz | Spanish La Liga |
| 7 | Thu 28 Sep | 61-1 v GranadaGranada 1-1 Real Betis | Spanish La Liga |
| 8 | Sun 1 Oct | 6 3-0 v ValenciaReal Betis 3-0 Valencia | Spanish La Liga |
| 9 | Thu 5 Oct | 62-1 v Sparta PragueReal Betis 2-1 Sparta Prague | UEFA Europa League Group C |
| 10 | Sun 8 Oct | 61-1 v AlavésAlavés 1-1 Real Betis | Spanish La Liga |
| 11 | Sat 21 Oct | 6 1-1 v GetafeGetafe 1-1 Real Betis | Spanish La Liga |
| 12 | Thu 26 Oct | 61-0 v Aris LimassolAris Limassol 0-1 Real Betis | UEFA Europa League Group C |
| 13 | Sun 29 Oct | 62-1 v OsasunaReal Betis 2-1 Osasuna | Spanish La Liga |
| 14 | Sat 4 Nov | 6 2-0 v MallorcaReal Betis 2-0 Mallorca | Spanish La Liga |
| 15 | Thu 9 Nov | 64-1 v Aris LimassolReal Betis 4-1 Aris Limassol | UEFA Europa League Group C |
| 16 | Sun 12 Nov | 61-1 v SevillaSevilla 1-1 Real Betis | Spanish La Liga |
| 17 | Sun 26 Nov | 61-0 v Las PalmasReal Betis 1-0 Las Palmas | Spanish La Liga |
| 18 | Thu 30 Nov | 6 0-1 v Sparta PragueSparta Prague 1-0 Real Betis | UEFA Europa League Group C |
| 19 | Sun 3 Dec | 60-0 v AlmeríaAlmería 0-0 Real Betis | Spanish La Liga |
| 20 | Sat 9 Dec | 61-1 v Real MadridReal Betis 1-1 Real Madrid | Spanish La Liga |
| 21 | Thu 14 Dec | 62-3 v RangersReal Betis 2-3 Rangers | UEFA Europa League Group C |
| 22 | Sun 17 Dec | 60-0 v Real SociedadReal Sociedad 0-0 Real Betis | Spanish La Liga |
| 23 | Thu 21 Dec | 61-1 v GironaReal Betis 1-1 Girona | Spanish La Liga |
| 24 | Wed 3 Jan | 61-2 v Celta VigoCelta Vigo 2-1 Real Betis | Spanish La Liga |
| 25 | Sat 13 Jan | 61-0 v GranadaReal Betis 1-0 Granada | Spanish La Liga |
| 26 | Sun 21 Jan | 62-4 v BarcelonaReal Betis 2-4 Barcelona | Spanish La Liga |
| 27 | Sat 27 Jan | 61-0 v MallorcaMallorca 0-1 Real Betis | Spanish La Liga |
| 28 | Sun 4 Feb | 61-1 v GetafeReal Betis 1-1 Getafe | Spanish La Liga |
| 29 | Fri 9 Feb | 62-0 v CádizCádiz 0-2 Real Betis | Spanish La Liga |
| 30 | Thu 15 Feb | 6 0-1 v Dinamo ZagrebReal Betis 0-1 Dinamo Zagreb | UEFA Europa Conference League |
| 31 | Sun 18 Feb | 6 0-0 v AlavésReal Betis 0-0 Alavés | Spanish La Liga |
| 32 | Sun 25 Feb | 63-1 v Athletic BilbaoReal Betis 3-1 Athletic Bilbao | Spanish La Liga |
| 33 | Sun 3 Mar | 6 1-2 v Atlético MadridAtlético Madrid 2-1 Real Betis | Spanish La Liga |
| 34 | Sun 17 Mar | 6 0-2 v Rayo VallecanoRayo Vallecano 2-0 Real Betis | Spanish La Liga |
| 35 | Sun 31 Mar | 62-3 v GironaGirona 3-2 Real Betis | Spanish La Liga |
| 36 | Fri 12 Apr | 6 2-1 v Celta VigoReal Betis 2-1 Celta Vigo | Spanish La Liga |
| 37 | Sat 20 Apr | 62-1 v ValenciaValencia 1-2 Real Betis | Spanish La Liga |
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