| 1 | Thu 22 Aug | 62-0 v Kryvbas KRKryvbas KR 0-2 Real Betis | UEFA Europa Conference League Play-off |
| 2 | Sun 25 Aug | 60-0 v AlavésAlavés 0-0 Real Betis | Spanish La Liga |
| 3 | Thu 29 Aug | 63-0 v Kryvbas KRReal Betis 3-0 Kryvbas KR | UEFA Europa Conference League Play-off |
| 4 | Sun 1 Sep | 60-2 v Real MadridReal Madrid 2-0 Real Betis | Spanish La Liga |
| 5 | Fri 13 Sep | 62-0 v LeganésReal Betis 2-0 Leganés | Spanish La Liga |
| 6 | Wed 18 Sep | 62-1 v GetafeReal Betis 2-1 Getafe | Spanish La Liga |
| 7 | Mon 23 Sep | 61-2 v MallorcaReal Betis 1-2 Mallorca | Spanish La Liga |
| 8 | Thu 26 Sep | 61-1 v Las PalmasLas Palmas 1-1 Real Betis | Spanish La Liga |
| 9 | Sun 29 Sep | 61-0 v EspanyolReal Betis 1-0 Espanyol | Spanish La Liga |
| 10 | Thu 3 Oct | 6 0-1 v Legia WarsawLegia Warsaw 1-0 Real Betis | UEFA Europa Conference League Matchday 1 |
| 11 | Sun 6 Oct | 6 0-1 v SevillaSevilla 1-0 Real Betis | Spanish La Liga |
| 12 | Sat 19 Oct | 6 2-1 v OsasunaOsasuna 1-2 Real Betis | Spanish La Liga |
| 13 | Thu 24 Oct | 61-1 v FC CopenhagenReal Betis 1-1 FC Copenhagen | UEFA Europa Conference League Matchday 2 |
| 14 | Sun 3 Nov | 61-1 v Athletic BilbaoAthletic Bilbao 1-1 Real Betis | Spanish La Liga |
| 15 | Thu 7 Nov | 62-1 v CeljeReal Betis 2-1 Celje | UEFA Europa Conference League Matchday 3 |
| 16 | Sun 10 Nov | 6 2-2 v Celta VigoReal Betis 2-2 Celta Vigo | Spanish La Liga |
| 17 | Sat 23 Nov | 62-4 v ValenciaValencia 4-2 Real Betis | Spanish La Liga |
| 18 | Thu 28 Nov | 6 1-2 v Mladá BoleslavMladá Boleslav 2-1 Real Betis | UEFA Europa Conference League Matchday 4 |
| 19 | Thu 12 Dec | 61-0 v Petrocub-HincestiPetrocub-Hincesti 0-1 Real Betis | UEFA Europa Conference League Matchday 5 |
| 20 | Sun 15 Dec | 62-1 v VillarrealVillarreal 1-2 Real Betis | Spanish La Liga |
| 21 | Thu 19 Dec | 61-0 v HJK HelsinkiReal Betis 1-0 HJK Helsinki | UEFA Europa Conference League Matchday 6 |
| 22 | Sat 11 Jan | 60-1 v Real ValladolidReal Valladolid 1-0 Real Betis | Spanish La Liga |
| 23 | Sat 18 Jan | 61-3 v AlavésReal Betis 1-3 Alavés | Spanish La Liga |
| 24 | Sat 25 Jan | 61-0 v MallorcaMallorca 0-1 Real Betis | Spanish La Liga |
| 25 | Sun 2 Feb | 62-2 v Athletic BilbaoReal Betis 2-2 Athletic Bilbao | Spanish La Liga |
| 26 | Sat 8 Feb | 62-3 v Celta VigoCelta Vigo 3-2 Real Betis | Spanish La Liga |
| 27 | Thu 13 Feb | 63-0 v KAA GentKAA Gent 0-3 Real Betis | UEFA Europa Conference League Knockout Round |
| 28 | Thu 20 Feb | 60-1 v KAA GentReal Betis 0-1 KAA Gent | UEFA Europa Conference League Knockout Round |
| 29 | Sun 23 Feb | 62-1 v GetafeGetafe 1-2 Real Betis | Spanish La Liga |
| 30 | Sat 1 Mar | 62-1 v Real MadridReal Betis 2-1 Real Madrid | Spanish La Liga |
| 31 | Thu 6 Mar | 62-2 v Vitória GuimarãesReal Betis 2-2 Vitória Guimarães | UEFA Europa Conference League Round of 16 |
| 32 | Sun 9 Mar | 61-0 v Las PalmasReal Betis 1-0 Las Palmas | Spanish La Liga |
| 33 | Thu 13 Mar | 64-0 v Vitória GuimarãesVitória Guimarães 0-4 Real Betis | UEFA Europa Conference League Round of 16 |
| 34 | Sun 16 Mar | 63-2 v LeganésLeganés 2-3 Real Betis | Spanish La Liga |
| 35 | Sat 5 Apr | 6 1-1 v BarcelonaBarcelona 1-1 Real Betis | Spanish La Liga |
| 36 | Thu 10 Apr | 62-0 v Jagiellonia BiałystokReal Betis 2-0 Jagiellonia Białystok | UEFA Europa Conference League Quarter Final |
| 37 | Sun 13 Apr | 61-2 v VillarrealReal Betis 1-2 Villarreal | Spanish La Liga |
| 38 | Thu 17 Apr | 61-1 v Jagiellonia BiałystokJagiellonia Białystok 1-1 Real Betis | UEFA Europa Conference League Quarter Final |
| 39 | Mon 21 Apr | 63-1 v GironaGirona 1-3 Real Betis | Spanish La Liga |
| 40 | Thu 24 Apr | 65-1 v Real ValladolidReal Betis 5-1 Real Valladolid | Spanish La Liga |
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