| 1 | 31/7/2021 | 461-1 v KAS EupenKAS Eupen 1-1 RSC Anderlecht | Belgian First Division A |
| 2 | 15/8/2021 | 462-1 v Cercle BruggeCercle Brugge 1-2 RSC Anderlecht | Belgian First Division A |
| 3 | 26/8/2021 | 461-2 v VitesseVitesse 2-1 RSC Anderlecht | UEFA Europa Conference League |
| 4 | 29/8/2021 | 460-1 v KRC GenkKRC Genk 1-0 RSC Anderlecht | Belgian First Division A |
| 5 | 12/9/2021 | 467-2 v MechelenRSC Anderlecht 7-2 Mechelen | Belgian First Division A |
| 6 | 19/9/2021 | 461-0 v Standard LiègeStandard Liège 0-1 RSC Anderlecht | Belgian First Division A |
| 7 | 23/9/2021 | 461-1 v KAA GentRSC Anderlecht 1-1 KAA Gent | Belgian First Division A |
| 8 | 3/10/2021 | 461-1 v Club BruggeRSC Anderlecht 1-1 Club Brugge | Belgian First Division A |
| 9 | 17/10/2021 | 462-2 v Sint-Truidense VVSint-Truidense VV 2-2 RSC Anderlecht | Belgian First Division A |
| 10 | 24/10/2021 | 46 4-2 v Germinal BeerschotRSC Anderlecht 4-2 Germinal Beerschot | Belgian First Division A |
| 11 | 31/10/2021 | 462-2 v Oud-Heverlee LeuvenRSC Anderlecht 2-2 Oud-Heverlee Leuven | Belgian First Division A |
| 12 | 7/11/2021 | 460-2 v Royal AntwerpRoyal Antwerp 2-0 RSC Anderlecht | Belgian First Division A |
| 13 | 21/11/2021 | 461-1 v KV KortrijkRSC Anderlecht 1-1 KV Kortrijk | Belgian First Division A |
| 14 | 27/11/2021 | 463-1 v Sporting de CharleroiSporting de Charleroi 1-3 RSC Anderlecht | Belgian First Division A |
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