| 1 | Sat 27 Jul | 541-0 v Sint-Truidense VVRSC Anderlecht 1-0 Sint-Truidense VV | Belgian First Division A |
| 2 | Sun 4 Aug | 542-1 v Royal AntwerpRoyal Antwerp 1-2 RSC Anderlecht | Belgian First Division A |
| 3 | Sat 10 Aug | 54 1-1 v Oud-Heverlee LeuvenRSC Anderlecht 1-1 Oud-Heverlee Leuven | Belgian First Division A |
| 4 | Sat 17 Aug | 543-1 v MechelenMechelen 1-3 RSC Anderlecht | Belgian First Division A |
| 5 | Thu 22 Aug | 541-0 v Dinamo MinskDinamo Minsk 0-1 RSC Anderlecht | UEFA Europa League Play-off |
| 6 | Thu 29 Aug | 541-0 v Dinamo MinskRSC Anderlecht 1-0 Dinamo Minsk | UEFA Europa League Play-off |
| 7 | Sun 1 Sep | 54 0-0 v Union Saint-GilloiseUnion Saint-Gilloise 0-0 RSC Anderlecht | Belgian First Division A |
| 8 | Sat 14 Sep | 542-2 v KVC WesterloRSC Anderlecht 2-2 KVC Westerlo | Belgian First Division A |
| 9 | Tue 17 Sep | 540-2 v KRC GenkRSC Anderlecht 0-2 KRC Genk | Belgian First Division A |
| 10 | Sat 21 Sep | 54 0-0 v Sporting de CharleroiRSC Anderlecht 0-0 Sporting de Charleroi | Belgian First Division A |
| 11 | Wed 25 Sep | 542-1 v Ferencvárosi TCRSC Anderlecht 2-1 Ferencvárosi TC | UEFA Europa League Matchday 1 |
| 12 | Sat 28 Sep | 541-1 v FCV Dender EHFCV Dender EH 1-1 RSC Anderlecht | Belgian First Division A |
| 13 | Thu 3 Oct | 542-1 v Real SociedadReal Sociedad 1-2 RSC Anderlecht | UEFA Europa League Matchday 2 |
| 14 | Sun 6 Oct | 54 3-0 v Standard LiègeRSC Anderlecht 3-0 Standard Liège | Belgian First Division A |
| 15 | Fri 18 Oct | 541-2 v Germinal BeerschotGerminal Beerschot 2-1 RSC Anderlecht | Belgian First Division A |
| 16 | Thu 24 Oct | 54 2-0 v LudogoretsRSC Anderlecht 2-0 Ludogorets | UEFA Europa League Matchday 3 |
| 17 | Sun 27 Oct | 541-2 v Club BruggeClub Brugge 2-1 RSC Anderlecht | Belgian First Division A |
| 18 | Sun 3 Nov | 544-0 v KV KortrijkRSC Anderlecht 4-0 KV Kortrijk | Belgian First Division A |
| 19 | Thu 7 Nov | 541-1 v Rīgas FSRīgas FS 1-1 RSC Anderlecht | UEFA Europa League Matchday 4 |
| 20 | Sun 10 Nov | 545-0 v Cercle BruggeCercle Brugge 0-5 RSC Anderlecht | Belgian First Division A |
| 21 | Sun 24 Nov | 546-0 v KAA GentRSC Anderlecht 6-0 KAA Gent | Belgian First Division A |
| 22 | Fri 27 Dec | 542-3 v FCV Dender EHRSC Anderlecht 2-3 FCV Dender EH | Belgian First Division A |
| 23 | Sun 12 Jan | 540-3 v Club BruggeRSC Anderlecht 0-3 Club Brugge | Belgian First Division A |
| 24 | Sun 19 Jan | 542-0 v KV KortrijkKV Kortrijk 0-2 RSC Anderlecht | Belgian First Division A |
| 25 | Thu 23 Jan | 540-2 v Viktoria PlzenViktoria Plzen 2-0 RSC Anderlecht | UEFA Europa League Matchday 7 |
| 26 | Sun 26 Jan | 544-1 v MechelenRSC Anderlecht 4-1 Mechelen | Belgian First Division A |
| 27 | Thu 30 Jan | 543-4 v 1899 HoffenheimRSC Anderlecht 3-4 1899 Hoffenheim | UEFA Europa League Matchday 8 |
| 28 | Sun 2 Feb | 540-1 v KAA GentKAA Gent 1-0 RSC Anderlecht | Belgian First Division A |
| 29 | Sun 9 Feb | 54 2-0 v Royal AntwerpRSC Anderlecht 2-0 Royal Antwerp | Belgian First Division A |
| 30 | Thu 13 Feb | 540-3 v FenerbahçeFenerbahçe 3-0 RSC Anderlecht | UEFA Europa League Play-off Knockout Round |
| 31 | Thu 20 Feb | 542-2 v FenerbahçeRSC Anderlecht 2-2 Fenerbahçe | UEFA Europa League Play-off Knockout Round |
| 32 | Sun 23 Feb | 54 0-2 v Union Saint-GilloiseRSC Anderlecht 0-2 Union Saint-Gilloise | Belgian First Division A |
| 33 | Sun 2 Mar | 542-0 v Standard LiègeStandard Liège 0-2 RSC Anderlecht | Belgian First Division A |
| 34 | Sun 9 Mar | 540-2 v KVC WesterloKVC Westerlo 2-0 RSC Anderlecht | Belgian First Division A |
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