| 1 | 8/8/2021 | 71-1 v LorientSaint Étienne 1-1 Lorient | French Ligue 1 |
| 2 | 22/9/2021 | 71-3 v MonacoMonaco 3-1 Saint Étienne | French Ligue 1 |
| 3 | 25/9/2021 | 70-3 v NiceSaint Étienne 0-3 Nice | French Ligue 1 |
| 4 | 3/10/2021 | 71-1 v LyonSaint Étienne 1-1 Lyon | French Ligue 1 |
| 5 | 17/10/2021 | 71-5 v StrasbourgStrasbourg 5-1 Saint Étienne | French Ligue 1 |
| 6 | 22/10/2021 | 72-2 v AngersSaint Étienne 2-2 Angers | French Ligue 1 |
| 7 | 30/10/2021 | 71-1 v MetzMetz 1-1 Saint Étienne | French Ligue 1 |
| 8 | 28/11/2021 | 7 1-3 v Paris St GermainSaint Étienne 1-3 Paris St Germain | French Ligue 1 |
| 9 | 1/12/2021 | 70-1 v BrestBrest 1-0 Saint Étienne | French Ligue 1 |
| 10 | 5/12/2021 | 70-5 v RennesSaint Étienne 0-5 Rennes | French Ligue 1 |
| 11 | 11/12/2021 | 70-2 v ReimsReims 2-0 Saint Étienne | French Ligue 1 |
| 12 | 22/12/2021 | 70-1 v NantesSaint Étienne 0-1 Nantes | French Ligue 1 |
| 13 | 15/1/2022 | 71-2 v LensSaint Étienne 1-2 Lens | French Ligue 1 |
| 14 | 26/1/2022 | 71-0 v AngersAngers 0-1 Saint Étienne | French Ligue 1 |
| 15 | 5/2/2022 | 73-1 v MontpellierSaint Étienne 3-1 Montpellier | French Ligue 1 |
| 16 | 13/2/2022 | 7 2-1 v ClermontClermont 1-2 Saint Étienne | French Ligue 1 |
| 17 | 20/2/2022 | 72-2 v StrasbourgSaint Étienne 2-2 Strasbourg | French Ligue 1 |
| 18 | 26/2/2022 | 71-3 v Paris St GermainParis St Germain 3-1 Saint Étienne | French Ligue 1 |
| 19 | 6/3/2022 | 71-0 v MetzSaint Étienne 1-0 Metz | French Ligue 1 |
| 20 | 11/3/2022 | 70-0 v LilleLille 0-0 Saint Étienne | French Ligue 1 |
| 21 | 18/3/2022 | 71-1 v TroyesSaint Étienne 1-1 Troyes | French Ligue 1 |
| 22 | 3/4/2022 | 72-4 v MarseilleSaint Étienne 2-4 Marseille | French Ligue 1 |
| 23 | 8/4/2022 | 72-6 v LorientLorient 6-2 Saint Étienne | French Ligue 1 |
| 24 | 16/4/2022 | 72-1 v BrestSaint Étienne 2-1 Brest | French Ligue 1 |
| 25 | 20/4/2022 | 72-2 v BordeauxBordeaux 2-2 Saint Étienne | French Ligue 1 |
| 26 | 23/4/2022 | 71-4 v MonacoSaint Étienne 1-4 Monaco | French Ligue 1 |
| 27 | 11/5/2022 | 72-4 v NiceNice 4-2 Saint Étienne | French Ligue 1 |
| 28 | 14/5/2022 | 71-2 v ReimsSaint Étienne 1-2 Reims | French Ligue 1 |
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