| 1 | Fri 4 Aug | 222-1 v Sheffield WednesdaySheffield Wednesday 1-2 Southampton | Sky Bet Championship |
| 2 | Sat 12 Aug | 224-4 v Norwich CitySouthampton 4-4 Norwich City | Sky Bet Championship |
| 3 | Sat 26 Aug | 22 2-1 v Queens Park RangersSouthampton 2-1 Queens Park Rangers | Sky Bet Championship |
| 4 | Sat 2 Sep | 220-5 v SunderlandSunderland 5-0 Southampton | Sky Bet Championship |
| 5 | Fri 15 Sep | 221-4 v Leicester CitySouthampton 1-4 Leicester City | Sky Bet Championship |
| 6 | Tue 19 Sep | 220-1 v Ipswich TownSouthampton 0-1 Ipswich Town | Sky Bet Championship |
| 7 | Sat 30 Sep | 223-1 v Leeds UnitedSouthampton 3-1 Leeds United | Sky Bet Championship |
| 8 | Tue 3 Oct | 221-0 v Stoke CityStoke City 0-1 Southampton | Sky Bet Championship |
| 9 | Sat 7 Oct | 221-1 v Rotherham UnitedSouthampton 1-1 Rotherham United | Sky Bet Championship |
| 10 | Sat 21 Oct | 22 2-1 v Hull CityHull City 1-2 Southampton | Sky Bet Championship |
| 11 | Wed 25 Oct | 222-2 v Preston North EndPreston North End 2-2 Southampton | Sky Bet Championship |
| 12 | Sat 28 Oct | 223-1 v Birmingham CitySouthampton 3-1 Birmingham City | Sky Bet Championship |
| 13 | Sat 4 Nov | 221-0 v MillwallMillwall 0-1 Southampton | Sky Bet Championship |
| 14 | Sat 11 Nov | 22 2-1 v West Bromwich AlbionSouthampton 2-1 West Bromwich Albion | Sky Bet Championship |
| 15 | Wed 29 Nov | 221-0 v Bristol CitySouthampton 1-0 Bristol City | Sky Bet Championship |
| 16 | Sat 2 Dec | 222-0 v Cardiff CitySouthampton 2-0 Cardiff City | Sky Bet Championship |
| 17 | Sat 9 Dec | 221-1 v WatfordWatford 1-1 Southampton | Sky Bet Championship |
| 18 | Wed 13 Dec | 221-1 v Coventry CityCoventry City 1-1 Southampton | Sky Bet Championship |
| 19 | Sat 16 Dec | 224-0 v Blackburn RoversSouthampton 4-0 Blackburn Rovers | Sky Bet Championship |
| 20 | Tue 26 Dec | 225-0 v Swansea CitySouthampton 5-0 Swansea City | Sky Bet Championship |
| 21 | Fri 29 Dec | 22 2-1 v Plymouth ArgyleSouthampton 2-1 Plymouth Argyle | Sky Bet Championship |
| 22 | Mon 1 Jan | 221-1 v Norwich CityNorwich City 1-1 Southampton | Sky Bet Championship |
| 23 | Sat 6 Jan | 224-0 v WalsallSouthampton 4-0 Walsall | Emirates FA Cup Third Round |
| 24 | Sat 13 Jan | 224-0 v Sheffield WednesdaySouthampton 4-0 Sheffield Wednesday | Sky Bet Championship |
| 25 | Sun 28 Jan | 22 1-1 v WatfordWatford 1-1 Southampton | Emirates FA Cup Fourth Round |
| 26 | Sun 4 Feb | 260-1 v Inter MilanInter Milan 1-0 Juventus | Italian Serie A |
| 27 | Sun 25 Feb | 263-2 v FrosinoneJuventus 3-2 Frosinone | Italian Serie A |
| 28 | Sun 3 Mar | 261-2 v NapoliNapoli 2-1 Juventus | Italian Serie A |
| 29 | Sun 7 Apr | 261-0 v FiorentinaJuventus 1-0 Fiorentina | Italian Serie A |
| 30 | Sat 13 Apr | 260-0 v TorinoTorino 0-0 Juventus | Italian Serie A |
| 31 | Fri 19 Apr | 262-2 v CagliariCagliari 2-2 Juventus | Italian Serie A |
| 32 | Sun 5 May | 261-1 v RomaRoma 1-1 Juventus | Italian Serie A |
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