| 1 | Sun 17 Oct 2021 | 31-0 v Celta VigoCelta Vigo 0-1 Sevilla | Spanish La Liga |
| 2 | Wed 20 Oct 2021 | 30-0 v LilleLille 0-0 Sevilla | UEFA Champions League Group G |
| 3 | Sun 24 Oct 2021 | 35-3 v LevanteSevilla 5-3 Levante | Spanish La Liga |
| 4 | Wed 27 Oct 2021 | 31-1 v MallorcaMallorca 1-1 Sevilla | Spanish La Liga |
| 5 | Sun 7 Nov 2021 | 32-0 v Real BetisReal Betis 0-2 Sevilla | Spanish La Liga |
| 6 | Sat 20 Nov 2021 | 32-2 v AlavésSevilla 2-2 Alavés | Spanish La Liga |
| 7 | Tue 23 Nov 2021 | 32-0 v VfL WolfsburgSevilla 2-0 VfL Wolfsburg | UEFA Champions League Group G |
| 8 | Sat 4 Dec 2021 | 31-0 v VillarrealSevilla 1-0 Villarreal | Spanish La Liga |
| 9 | Wed 8 Dec 2021 | 3 0-1 v SV Red Bull SalzburgSV Red Bull Salzburg 1-0 Sevilla | UEFA Champions League Group G |
| 10 | Sat 11 Dec 2021 | 31-0 v Athletic BilbaoAthletic Bilbao 0-1 Sevilla | Spanish La Liga |
| 11 | Sat 18 Dec 2021 | 32-1 v Atlético MadridSevilla 2-1 Atlético Madrid | Spanish La Liga |
| 12 | Tue 21 Dec 2021 | 31-1 v BarcelonaSevilla 1-1 Barcelona | Spanish La Liga |
| 13 | Mon 3 Jan 2022 | 3 1-0 v CádizCádiz 0-1 Sevilla | Spanish La Liga |
| 14 | Sun 20 Feb 2022 | 3 1-1 v EspanyolEspanyol 1-1 Sevilla | Spanish La Liga |
| 15 | Sun 27 Feb 2022 | 3 2-1 v Real BetisSevilla 2-1 Real Betis | Spanish La Liga |
| 16 | Fri 4 Mar 2022 | 30-0 v AlavésAlavés 0-0 Sevilla | Spanish La Liga |
| 17 | Thu 10 Mar 2022 | 31-0 v West Ham UnitedSevilla 1-0 West Ham United | UEFA Europa League Round of 16 |
| 18 | Sun 13 Mar 2022 | 31-1 v Rayo VallecanoRayo Vallecano 1-1 Sevilla | Spanish La Liga |
| 19 | Thu 17 Mar 2022 | 30-2 v West Ham UnitedWest Ham United 2-0 Sevilla | UEFA Europa League Round of 16 |
| 20 | Sun 20 Mar 2022 | 30-0 v Real SociedadSevilla 0-0 Real Sociedad | Spanish La Liga |
| 21 | Sun 3 Apr 2022 | 30-1 v BarcelonaBarcelona 1-0 Sevilla | Spanish La Liga |
| 22 | Fri 8 Apr 2022 | 34-2 v GranadaSevilla 4-2 Granada | Spanish La Liga |
| 23 | Sun 17 Apr 2022 | 32-3 v Real MadridSevilla 2-3 Real Madrid | Spanish La Liga |
| 24 | Thu 21 Apr 2022 | 33-2 v LevanteLevante 2-3 Sevilla | Spanish La Liga |
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