| 1 | 7/8/2021 | 160-1 v Birmingham CitySheffield United 0-1 Birmingham City | Sky Bet Championship |
| 2 | 14/8/2021 | 160-0 v Swansea CitySwansea City 0-0 Sheffield United | Sky Bet Championship |
| 3 | 18/8/2021 | 160-4 v West Bromwich AlbionWest Bromwich Albion 4-0 Sheffield United | Sky Bet Championship |
| 4 | 21/8/2021 | 161-2 v Huddersfield TownSheffield United 1-2 Huddersfield Town | Sky Bet Championship |
| 5 | 28/8/2021 | 160-0 v Luton TownLuton Town 0-0 Sheffield United | Sky Bet Championship |
| 6 | 11/9/2021 | 166-2 v Peterborough UnitedSheffield United 6-2 Peterborough United | Sky Bet Championship |
| 7 | 14/9/2021 | 16 2-2 v Preston North EndSheffield United 2-2 Preston North End | Sky Bet Championship |
| 8 | 18/9/2021 | 163-1 v Hull CityHull City 1-3 Sheffield United | Sky Bet Championship |
| 9 | 21/9/2021 | 162-2 v SouthamptonSheffield United 2-2 Southampton | Carabao Cup Third Round |
| 10 | 25/9/2021 | 161-0 v Derby CountySheffield United 1-0 Derby County | Sky Bet Championship |
| 11 | 28/9/2021 | 160-2 v MiddlesbroughMiddlesbrough 2-0 Sheffield United | Sky Bet Championship |
| 12 | 2/10/2021 | 161-2 v AFC BournemouthAFC Bournemouth 2-1 Sheffield United | Sky Bet Championship |
| 13 | 16/10/2021 | 162-1 v Stoke CitySheffield United 2-1 Stoke City | Sky Bet Championship |
| 14 | 24/10/2021 | 163-2 v BarnsleyBarnsley 2-3 Sheffield United | Sky Bet Championship |
| 15 | 30/10/2021 | 16 0-1 v BlackpoolSheffield United 0-1 Blackpool | Sky Bet Championship |
| 16 | 2/11/2021 | 16 1-1 v Nottingham ForestNottingham Forest 1-1 Sheffield United | Sky Bet Championship |
| 17 | 6/11/2021 | 16 1-3 v Blackburn RoversBlackburn Rovers 3-1 Sheffield United | Sky Bet Championship |
| 18 | 23/11/2021 | 161-0 v ReadingReading 0-1 Sheffield United | Sky Bet Championship |
| 19 | 28/11/2021 | 162-0 v Bristol CitySheffield United 2-0 Bristol City | Sky Bet Championship |
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