| 1 | Sun 1 Aug 2021 | 210-0 v Huddersfield TownSheffield Wednesday 0-0 Huddersfield Town | Carabao Cup First Round |
| 2 | Sat 21 Aug 2021 | 212-0 v Rotherham UnitedRotherham United 0-2 Sheffield Wednesday | Sky Bet League One |
| 3 | Tue 9 Nov 2021 | 214-0 v Harrogate TownSheffield Wednesday 4-0 Harrogate Town | Papa John’s Trophy |
| 4 | Tue 16 Nov 2021 | 210-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 5 | Sat 20 Nov 2021 | 21 3-2 v Accrington StanleyAccrington Stanley 2-3 Sheffield Wednesday | Sky Bet League One |
| 6 | Tue 23 Nov 2021 | 212-1 v Milton Keynes DonsSheffield Wednesday 2-1 Milton Keynes Dons | Sky Bet League One |
| 7 | Sat 27 Nov 2021 | 21 2-2 v Wycombe WanderersSheffield Wednesday 2-2 Wycombe Wanderers | Sky Bet League One |
| 8 | Tue 7 Dec 2021 | 21 0-0 v PortsmouthPortsmouth 0-0 Sheffield Wednesday | Sky Bet League One |
| 9 | Sat 15 Jan 2022 | 21 4-2 v Plymouth ArgyleSheffield Wednesday 4-2 Plymouth Argyle | Sky Bet League One |
| 10 | Sat 22 Jan 2022 | 212-3 v Oxford UnitedOxford United 3-2 Sheffield Wednesday | Sky Bet League One |
| 11 | Sat 29 Jan 2022 | 211-0 v Ipswich TownSheffield Wednesday 1-0 Ipswich Town | Sky Bet League One |
| 12 | Sat 5 Feb 2022 | 21 2-0 v Burton AlbionBurton Albion 0-2 Sheffield Wednesday | Sky Bet League One |
| 13 | Tue 8 Feb 2022 | 211-0 v Wigan AthleticSheffield Wednesday 1-0 Wigan Athletic | Sky Bet League One |
| 14 | Sun 13 Feb 2022 | 210-2 v Rotherham UnitedSheffield Wednesday 0-2 Rotherham United | Sky Bet League One |
| 15 | Sat 19 Feb 2022 | 213-1 v Doncaster RoversDoncaster Rovers 1-3 Sheffield Wednesday | Sky Bet League One |
| 16 | Sat 26 Feb 2022 | 212-0 v Charlton AthleticSheffield Wednesday 2-0 Charlton Athletic | Sky Bet League One |
| 17 | Tue 1 Mar 2022 | 215-2 v Burton AlbionSheffield Wednesday 5-2 Burton Albion | Sky Bet League One |
| 18 | Sat 5 Mar 2022 | 211-3 v Lincoln CityLincoln City 3-1 Sheffield Wednesday | Sky Bet League One |
| 19 | Sat 12 Mar 2022 | 216-0 v Cambridge UnitedSheffield Wednesday 6-0 Cambridge United | Sky Bet League One |
| 20 | Tue 15 Mar 2022 | 211-1 v Accrington StanleySheffield Wednesday 1-1 Accrington Stanley | Sky Bet League One |
| 21 | Sat 19 Mar 2022 | 210-0 v GillinghamGillingham 0-0 Sheffield Wednesday | Sky Bet League One |
| 22 | Sat 26 Mar 2022 | 214-1 v Cheltenham TownSheffield Wednesday 4-1 Cheltenham Town | Sky Bet League One |
| 23 | Sat 2 Apr 2022 | 212-1 v AFC WimbledonSheffield Wednesday 2-1 AFC Wimbledon | Sky Bet League One |
| 24 | Sat 9 Apr 2022 | 211-1 v Bolton WanderersBolton Wanderers 1-1 Sheffield Wednesday | Sky Bet League One |
| 25 | Tue 19 Apr 2022 | 21 1-0 v Crewe AlexandraSheffield Wednesday 1-0 Crewe Alexandra | Sky Bet League One |
| 26 | Sat 23 Apr 2022 | 210-1 v Wycombe WanderersWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet League One |
| 27 | Tue 26 Apr 2022 | 21 3-2 v Fleetwood TownFleetwood Town 2-3 Sheffield Wednesday | Sky Bet League One |
| 28 | Sat 30 Apr 2022 | 214-1 v PortsmouthSheffield Wednesday 4-1 Portsmouth | Sky Bet League One |
| 29 | Fri 6 May 2022 | 21 0-1 v SunderlandSunderland 1-0 Sheffield Wednesday | Sky Bet League One Play-off Semi Final |
| 30 | Mon 9 May 2022 | 211-1 v SunderlandSheffield Wednesday 1-1 Sunderland | Sky Bet League One Play-off Semi Final |
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