| 1 | Sun 1 Aug 2021 | 70-0 v Huddersfield TownSheffield Wednesday 0-0 Huddersfield Town | Carabao Cup First Round |
| 2 | Sat 11 Sep 2021 | 70-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Sky Bet League One |
| 3 | Sat 18 Sep 2021 | 71-1 v Shrewsbury TownSheffield Wednesday 1-1 Shrewsbury Town | Sky Bet League One |
| 4 | Sat 25 Sep 2021 | 71-1 v Ipswich TownIpswich Town 1-1 Sheffield Wednesday | Sky Bet League One |
| 5 | Tue 28 Sep 2021 | 72-1 v Wigan AthleticWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 6 | Sat 2 Oct 2021 | 71-2 v Oxford UnitedSheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 7 | Tue 5 Oct 2021 | 72-1 v Mansfield TownMansfield Town 1-2 Sheffield Wednesday | Papa John’s Trophy |
| 8 | Sat 9 Oct 2021 | 7 1-0 v Bolton WanderersSheffield Wednesday 1-0 Bolton Wanderers | Sky Bet League One |
| 9 | Tue 19 Oct 2021 | 71-1 v Cambridge UnitedCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 10 | Sat 23 Oct 2021 | 71-1 v Lincoln CitySheffield Wednesday 1-1 Lincoln City | Sky Bet League One |
| 11 | Sat 30 Oct 2021 | 72-2 v Cheltenham TownCheltenham Town 2-2 Sheffield Wednesday | Sky Bet League One |
| 12 | Sun 7 Nov 2021 | 70-0 v Plymouth ArgyleSheffield Wednesday 0-0 Plymouth Argyle | Emirates FA Cup First Round |
| 13 | Tue 9 Nov 2021 | 74-0 v Harrogate TownSheffield Wednesday 4-0 Harrogate Town | Papa John’s Trophy |
| 14 | Sat 13 Nov 2021 | 71-1 v GillinghamSheffield Wednesday 1-1 Gillingham | Sky Bet League One |
| 15 | Tue 16 Nov 2021 | 70-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 16 | Sat 27 Nov 2021 | 7 2-2 v Wycombe WanderersSheffield Wednesday 2-2 Wycombe Wanderers | Sky Bet League One |
| 17 | Tue 7 Dec 2021 | 70-0 v PortsmouthPortsmouth 0-0 Sheffield Wednesday | Sky Bet League One |
| 18 | Sat 11 Dec 2021 | 72-0 v Crewe AlexandraCrewe Alexandra 0-2 Sheffield Wednesday | Sky Bet League One |
| 19 | Sat 2 Apr 2022 | 72-1 v AFC WimbledonSheffield Wednesday 2-1 AFC Wimbledon | Sky Bet League One |
| 20 | Sat 23 Apr 2022 | 70-1 v Wycombe WanderersWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet League One |
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