| 1 | 1/8/2021 | 6 0-0 v Huddersfield TownSheffield Wednesday 0-0 Huddersfield Town | Carabao Cup First Round |
| 2 | 7/8/2021 | 6 0-0 v Charlton AthleticCharlton Athletic 0-0 Sheffield Wednesday | Sky Bet League One |
| 3 | 14/8/2021 | 62-0 v Doncaster RoversSheffield Wednesday 2-0 Doncaster Rovers | Sky Bet League One |
| 4 | 17/8/2021 | 6 1-0 v Fleetwood TownSheffield Wednesday 1-0 Fleetwood Town | Sky Bet League One |
| 5 | 21/8/2021 | 62-0 v Rotherham UnitedRotherham United 0-2 Sheffield Wednesday | Sky Bet League One |
| 6 | 28/8/2021 | 60-1 v MorecambeMorecambe 1-0 Sheffield Wednesday | Sky Bet League One |
| 7 | 11/9/2021 | 60-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Sky Bet League One |
| 8 | 18/9/2021 | 61-1 v Shrewsbury TownSheffield Wednesday 1-1 Shrewsbury Town | Sky Bet League One |
| 9 | 25/9/2021 | 61-1 v Ipswich TownIpswich Town 1-1 Sheffield Wednesday | Sky Bet League One |
| 10 | 28/9/2021 | 62-1 v Wigan AthleticWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 11 | 2/10/2021 | 61-2 v Oxford UnitedSheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 12 | 5/10/2021 | 62-1 v Mansfield TownMansfield Town 1-2 Sheffield Wednesday | Checkatrade Trophy |
| 13 | 9/10/2021 | 6 1-0 v Bolton WanderersSheffield Wednesday 1-0 Bolton Wanderers | Sky Bet League One |
| 14 | 16/10/2021 | 62-2 v AFC WimbledonAFC Wimbledon 2-2 Sheffield Wednesday | Sky Bet League One |
| 15 | 19/10/2021 | 61-1 v Cambridge UnitedCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 16 | 23/10/2021 | 61-1 v Lincoln CitySheffield Wednesday 1-1 Lincoln City | Sky Bet League One |
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