| 1 | 1/8/2021 | 170-0 v Huddersfield TownSheffield Wednesday 0-0 Huddersfield Town | Carabao Cup First Round |
| 2 | 17/8/2021 | 171-0 v Fleetwood TownSheffield Wednesday 1-0 Fleetwood Town | Sky Bet League One |
| 3 | 21/8/2021 | 172-0 v Rotherham UnitedRotherham United 0-2 Sheffield Wednesday | Sky Bet League One |
| 4 | 28/8/2021 | 170-1 v MorecambeMorecambe 1-0 Sheffield Wednesday | Sky Bet League One |
| 5 | 11/9/2021 | 170-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Sky Bet League One |
| 6 | 18/9/2021 | 171-1 v Shrewsbury TownSheffield Wednesday 1-1 Shrewsbury Town | Sky Bet League One |
| 7 | 25/9/2021 | 171-1 v Ipswich TownIpswich Town 1-1 Sheffield Wednesday | Sky Bet League One |
| 8 | 28/9/2021 | 172-1 v Wigan AthleticWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 9 | 2/10/2021 | 171-2 v Oxford UnitedSheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 10 | 5/10/2021 | 172-1 v Mansfield TownMansfield Town 1-2 Sheffield Wednesday | Checkatrade Trophy |
| 11 | 16/10/2021 | 172-2 v AFC WimbledonAFC Wimbledon 2-2 Sheffield Wednesday | Sky Bet League One |
| 12 | 19/10/2021 | 171-1 v Cambridge UnitedCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 13 | 23/10/2021 | 171-1 v Lincoln CitySheffield Wednesday 1-1 Lincoln City | Sky Bet League One |
| 14 | 30/10/2021 | 172-2 v Cheltenham TownCheltenham Town 2-2 Sheffield Wednesday | Sky Bet League One |
| 15 | 2/11/2021 | 173-0 v SunderlandSheffield Wednesday 3-0 Sunderland | Sky Bet League One |
| 16 | 7/11/2021 | 170-0 v Plymouth ArgyleSheffield Wednesday 0-0 Plymouth Argyle | Emirates FA Cup First Round |
| 17 | 9/11/2021 | 174-0 v Harrogate TownSheffield Wednesday 4-0 Harrogate Town | Checkatrade Trophy |
| 18 | 13/11/2021 | 171-1 v GillinghamSheffield Wednesday 1-1 Gillingham | Sky Bet League One |
| 19 | 16/11/2021 | 170-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup |
| 20 | 20/11/2021 | 173-2 v Accrington StanleyAccrington Stanley 2-3 Sheffield Wednesday | Sky Bet League One |
| 21 | 23/11/2021 | 172-1 v Milton Keynes DonsSheffield Wednesday 2-1 Milton Keynes Dons | Sky Bet League One |
| 22 | 27/11/2021 | 172-2 v Wycombe WanderersSheffield Wednesday 2-2 Wycombe Wanderers | Sky Bet League One |
| 23 | 7/12/2021 | 170-0 v PortsmouthPortsmouth 0-0 Sheffield Wednesday | Sky Bet League One |
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