| 1 | Sun 14 Jul 2019 | 41-1 v AltachAltach 1-1 Southampton | Friendly |
| 2 | Sat 3 Aug 2019 | 42-0 v 1. FC KölnSouthampton 2-0 1. FC Köln | Friendly |
| 3 | Sat 10 Aug 2019 | 40-3 v BurnleyBurnley 3-0 Southampton | Premier League |
| 4 | Sat 17 Aug 2019 | 41-2 v LiverpoolSouthampton 1-2 Liverpool | Premier League |
| 5 | Sat 24 Aug 2019 | 42-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-2 Southampton | Premier League |
| 6 | Sat 31 Aug 2019 | 41-1 v Manchester UnitedSouthampton 1-1 Manchester United | Premier League |
| 7 | Sat 14 Sep 2019 | 4 1-0 v Sheffield UnitedSheffield United 0-1 Southampton | Premier League |
| 8 | Fri 20 Sep 2019 | 41-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth | Premier League |
| 9 | Sat 19 Oct 2019 | 41-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Southampton | Premier League |
| 10 | Fri 25 Oct 2019 | 40-9 v Leicester CitySouthampton 0-9 Leicester City | Premier League |
| 11 | Sat 2 Nov 2019 | 41-2 v Manchester CityManchester City 2-1 Southampton | Premier League |
| 12 | Sat 9 Nov 2019 | 41-2 v EvertonSouthampton 1-2 Everton | Premier League |
| 13 | Sat 4 Jan 2020 | 42-0 v Huddersfield TownSouthampton 2-0 Huddersfield Town | Emirates FA Cup Third Round |
| 14 | Tue 21 Jan 2020 | 42-0 v Crystal PalaceCrystal Palace 0-2 Southampton | Premier League |
| 15 | Wed 5 Feb 2020 | 42-3 v Tottenham HotspurTottenham Hotspur 3-2 Southampton | Emirates FA Cup Fourth Round Replay |
| 16 | Sat 15 Feb 2020 | 4 1-2 v BurnleySouthampton 1-2 Burnley | Premier League |
| 17 | Sat 29 Feb 2020 | 41-3 v West Ham UnitedWest Ham United 3-1 Southampton | Premier League |
| 18 | Thu 25 Jun 2020 | 40-2 v ArsenalSouthampton 0-2 Arsenal | Premier League |
| 19 | Sun 28 Jun 2020 | 43-1 v WatfordWatford 1-3 Southampton | Premier League |
| 20 | Thu 16 Jul 2020 | 41-1 v Brighton & Hove AlbionSouthampton 1-1 Brighton & Hove Albion | Premier League |
| 21 | Sun 19 Jul 2020 | 4 2-0 v AFC BournemouthAFC Bournemouth 0-2 Southampton | Premier League |
| 22 | Sun 26 Jul 2020 | 43-1 v Sheffield UnitedSouthampton 3-1 Sheffield United | Premier League |
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