| 1 | Sun 25 Oct 2020 | 402-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 2 | Sun 29 Nov 2020 | 402-3 v Manchester UnitedSouthampton 2-3 Manchester United | Premier League |
| 3 | Sun 13 Dec 2020 | 403-0 v Sheffield UnitedSouthampton 3-0 Sheffield United | Premier League |
| 4 | Sat 19 Dec 2020 | 400-1 v Manchester CitySouthampton 0-1 Manchester City | Premier League |
| 5 | Sat 26 Dec 2020 | 400-0 v FulhamFulham 0-0 Southampton | Premier League |
| 6 | Mon 4 Jan 2021 | 401-0 v LiverpoolSouthampton 1-0 Liverpool | Premier League |
| 7 | Sat 16 Jan 2021 | 400-2 v Leicester CityLeicester City 2-0 Southampton | Premier League |
| 8 | Tue 19 Jan 2021 | 402-0 v Shrewsbury TownSouthampton 2-0 Shrewsbury Town | Emirates FA Cup Third Round |
| 9 | Sat 23 Jan 2021 | 401-0 v ArsenalSouthampton 1-0 Arsenal | Emirates FA Cup Fourth Round |
| 10 | Tue 26 Jan 2021 | 401-3 v ArsenalSouthampton 1-3 Arsenal | Premier League |
| 11 | Sat 6 Feb 2021 | 402-3 v Newcastle UnitedNewcastle United 3-2 Southampton | Premier League |
| 12 | Sat 20 Feb 2021 | 401-1 v ChelseaSouthampton 1-1 Chelsea | Premier League |
| 13 | Mon 1 Mar 2021 | 400-1 v EvertonEverton 1-0 Southampton | Premier League |
| 14 | Sun 14 Mar 2021 | 401-2 v Brighton & Hove AlbionSouthampton 1-2 Brighton & Hove Albion | Premier League |
| 15 | Sat 20 Mar 2021 | 403-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 16 | Fri 30 Apr 2021 | 401-1 v Leicester CitySouthampton 1-1 Leicester City | Premier League |
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