| 1 | Sat 17 Aug | 90-1 v Newcastle UnitedNewcastle United 1-0 Southampton | Premier League |
| 2 | Sat 24 Aug | 9 0-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 3 | Sat 31 Aug | 91-3 v BrentfordBrentford 3-1 Southampton | Premier League |
| 4 | Tue 17 Sep | 9 1-1 v EvertonEverton 1-1 Southampton | Carabao Cup Third Round |
| 5 | Sat 21 Sep | 91-1 v Ipswich TownSouthampton 1-1 Ipswich Town | Premier League |
| 6 | Sat 5 Oct | 91-3 v ArsenalArsenal 3-1 Southampton | Premier League |
| 7 | Sat 26 Oct | 9 0-1 v Manchester CityManchester City 1-0 Southampton | Premier League |
| 8 | Tue 29 Oct | 9 3-2 v Stoke CitySouthampton 3-2 Stoke City | Carabao Cup Round of 16 |
| 9 | Sat 2 Nov | 91-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 10 | Sat 9 Nov | 90-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 11 | Sun 24 Nov | 9 2-3 v LiverpoolSouthampton 2-3 Liverpool | Premier League |
| 12 | Fri 29 Nov | 91-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Southampton | Premier League |
| 13 | Wed 4 Dec | 9 1-5 v ChelseaSouthampton 1-5 Chelsea | Premier League |
| 14 | Sat 7 Dec | 90-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 15 | Sun 15 Dec | 90-5 v Tottenham HotspurSouthampton 0-5 Tottenham Hotspur | Premier League |
| 16 | Sun 22 Dec | 90-0 v FulhamFulham 0-0 Southampton | Premier League |
| 17 | Thu 26 Dec | 90-1 v West Ham UnitedSouthampton 0-1 West Ham United | Premier League |
| 18 | Sun 29 Dec | 91-2 v Crystal PalaceCrystal Palace 2-1 Southampton | Premier League |
| 19 | Sat 4 Jan | 90-5 v BrentfordSouthampton 0-5 Brentford | Premier League |
| 20 | Sun 12 Jan | 93-0 v Swansea CitySouthampton 3-0 Swansea City | Emirates FA Cup Third Round |
| 21 | Thu 16 Jan | 91-3 v Manchester UnitedManchester United 3-1 Southampton | Premier League |
| 22 | Sun 19 Jan | 92-3 v Nottingham ForestNottingham Forest 3-2 Southampton | Premier League |
| 23 | Sat 25 Jan | 91-3 v Newcastle UnitedSouthampton 1-3 Newcastle United | Premier League |
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