| 1 | Sat 17 Aug | 40-1 v Newcastle UnitedNewcastle United 1-0 Southampton | Premier League |
| 2 | Sat 24 Aug | 4 0-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 3 | Sat 31 Aug | 41-3 v BrentfordBrentford 3-1 Southampton | Premier League |
| 4 | Sat 14 Sep | 40-3 v Manchester UnitedSouthampton 0-3 Manchester United | Premier League |
| 5 | Tue 17 Sep | 41-1 v EvertonEverton 1-1 Southampton | Carabao Cup Third Round |
| 6 | Sat 21 Sep | 4 1-1 v Ipswich TownSouthampton 1-1 Ipswich Town | Premier League |
| 7 | Mon 30 Sep | 4 1-3 v AFC BournemouthAFC Bournemouth 3-1 Southampton | Premier League |
| 8 | Sat 5 Oct | 41-3 v ArsenalArsenal 3-1 Southampton | Premier League |
| 9 | Sat 19 Oct | 42-3 v Leicester CitySouthampton 2-3 Leicester City | Premier League |
| 10 | Sat 26 Oct | 4 0-1 v Manchester CityManchester City 1-0 Southampton | Premier League |
| 11 | Sat 2 Nov | 41-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 12 | Sat 9 Nov | 40-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 13 | Sun 24 Nov | 42-3 v LiverpoolSouthampton 2-3 Liverpool | Premier League |
| 14 | Fri 29 Nov | 4 1-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Southampton | Premier League |
| 15 | Sat 7 Dec | 4 0-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 16 | Sun 15 Dec | 40-5 v Tottenham HotspurSouthampton 0-5 Tottenham Hotspur | Premier League |
| 17 | Wed 18 Dec | 4 1-2 v LiverpoolSouthampton 1-2 Liverpool | Carabao Cup Quarter Final |
| 18 | Sun 22 Dec | 4 0-0 v FulhamFulham 0-0 Southampton | Premier League |
| 19 | Thu 26 Dec | 40-1 v West Ham UnitedSouthampton 0-1 West Ham United | Premier League |
| 20 | Thu 16 Jan | 4 1-3 v Manchester UnitedManchester United 3-1 Southampton | Premier League |
| 21 | Sun 19 Jan | 4 2-3 v Nottingham ForestNottingham Forest 3-2 Southampton | Premier League |
| 22 | Tue 25 Feb | 40-4 v ChelseaChelsea 4-0 Southampton | Premier League |
| 23 | Sat 15 Mar | 41-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 24 | Wed 2 Apr | 4 1-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 25 | Sat 19 Apr | 41-1 v West Ham UnitedWest Ham United 1-1 Southampton | Premier League |
| 26 | Sat 26 Apr | 41-2 v FulhamSouthampton 1-2 Fulham | Premier League |
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