| 1 | Sat 17 Aug | 5 0-1 v Newcastle UnitedNewcastle United 1-0 Southampton | Premier League |
| 2 | Sat 24 Aug | 50-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 3 | Sat 31 Aug | 51-3 v BrentfordBrentford 3-1 Southampton | Premier League |
| 4 | Sat 14 Sep | 5 0-3 v Manchester UnitedSouthampton 0-3 Manchester United | Premier League |
| 5 | Sat 26 Oct | 50-1 v Manchester CityManchester City 1-0 Southampton | Premier League |
| 6 | Sat 2 Nov | 51-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 7 | Sat 9 Nov | 50-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 8 | Sun 24 Nov | 5 2-3 v LiverpoolSouthampton 2-3 Liverpool | Premier League |
| 9 | Fri 29 Nov | 51-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Southampton | Premier League |
| 10 | Wed 4 Dec | 5 1-5 v ChelseaSouthampton 1-5 Chelsea | Premier League |
| 11 | Sat 1 Feb | 52-1 v Ipswich TownIpswich Town 1-2 Southampton | Premier League |
| 12 | Sat 15 Mar | 51-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 13 | Wed 2 Apr | 51-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 14 | Sat 12 Apr | 50-3 v Aston VillaSouthampton 0-3 Aston Villa | Premier League |
| 15 | Sat 19 Apr | 51-1 v West Ham UnitedWest Ham United 1-1 Southampton | Premier League |
| 16 | Sat 26 Apr | 51-2 v FulhamSouthampton 1-2 Fulham | Premier League |
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