| 1 | Sat 17 Aug | 70-1 v Newcastle UnitedNewcastle United 1-0 Southampton | Premier League |
| 2 | Sat 24 Aug | 70-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 3 | Sat 31 Aug | 71-3 v BrentfordBrentford 3-1 Southampton | Premier League |
| 4 | Tue 17 Sep | 71-1 v EvertonEverton 1-1 Southampton | Carabao Cup Third Round |
| 5 | Sat 21 Sep | 71-1 v Ipswich TownSouthampton 1-1 Ipswich Town | Premier League |
| 6 | Mon 30 Sep | 71-3 v AFC BournemouthAFC Bournemouth 3-1 Southampton | Premier League |
| 7 | Sat 5 Oct | 71-3 v ArsenalArsenal 3-1 Southampton | Premier League |
| 8 | Sat 19 Oct | 72-3 v Leicester CitySouthampton 2-3 Leicester City | Premier League |
| 9 | Sat 26 Oct | 70-1 v Manchester CityManchester City 1-0 Southampton | Premier League |
| 10 | Tue 29 Oct | 73-2 v Stoke CitySouthampton 3-2 Stoke City | Carabao Cup Round of 16 |
| 11 | Sat 2 Nov | 71-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 12 | Sun 24 Nov | 72-3 v LiverpoolSouthampton 2-3 Liverpool | Premier League |
| 13 | Fri 29 Nov | 71-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Southampton | Premier League |
| 14 | Wed 4 Dec | 71-5 v ChelseaSouthampton 1-5 Chelsea | Premier League |
| 15 | Sat 7 Dec | 70-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 16 | Sun 15 Dec | 70-5 v Tottenham HotspurSouthampton 0-5 Tottenham Hotspur | Premier League |
| 17 | Sun 22 Dec | 70-0 v FulhamFulham 0-0 Southampton | Premier League |
| 18 | Thu 26 Dec | 70-1 v West Ham UnitedSouthampton 0-1 West Ham United | Premier League |
| 19 | Sun 29 Dec | 71-2 v Crystal PalaceCrystal Palace 2-1 Southampton | Premier League |
| 20 | Sat 4 Jan | 70-5 v BrentfordSouthampton 0-5 Brentford | Premier League |
| 21 | Sun 12 Jan | 73-0 v Swansea CitySouthampton 3-0 Swansea City | Emirates FA Cup Third Round |
| 22 | Thu 16 Jan | 71-3 v Manchester UnitedManchester United 3-1 Southampton | Premier League |
| 23 | Sun 19 Jan | 7 2-3 v Nottingham ForestNottingham Forest 3-2 Southampton | Premier League |
| 24 | Sat 25 Jan | 71-3 v Newcastle UnitedSouthampton 1-3 Newcastle United | Premier League |
| 25 | Sat 1 Feb | 72-1 v Ipswich TownIpswich Town 1-2 Southampton | Premier League |
| 26 | Sat 8 Feb | 70-1 v BurnleySouthampton 0-1 Burnley | Emirates FA Cup Fourth Round |
| 27 | Sat 15 Feb | 71-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth | Premier League |
| 28 | Sat 22 Feb | 70-4 v Brighton & Hove AlbionSouthampton 0-4 Brighton & Hove Albion | Premier League |
| 29 | Tue 25 Feb | 70-4 v ChelseaChelsea 4-0 Southampton | Premier League |
| 30 | Sat 8 Mar | 71-3 v LiverpoolLiverpool 3-1 Southampton | Premier League |
| 31 | Sat 15 Mar | 71-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 32 | Wed 2 Apr | 71-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 33 | Sun 6 Apr | 71-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton | Premier League |
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