| 1 | Sat 5 Oct | 31-3 v ArsenalArsenal 3-1 Southampton | Premier League |
| 2 | Sat 19 Oct | 3 2-3 v Leicester CitySouthampton 2-3 Leicester City | Premier League |
| 3 | Sat 26 Oct | 30-1 v Manchester CityManchester City 1-0 Southampton | Premier League |
| 4 | Sat 2 Nov | 31-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 5 | Sat 9 Nov | 30-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 6 | Fri 29 Nov | 31-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Southampton | Premier League |
| 7 | Wed 4 Dec | 31-5 v ChelseaSouthampton 1-5 Chelsea | Premier League |
| 8 | Sat 7 Dec | 30-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 9 | Sun 15 Dec | 30-5 v Tottenham HotspurSouthampton 0-5 Tottenham Hotspur | Premier League |
| 10 | Wed 18 Dec | 31-2 v LiverpoolSouthampton 1-2 Liverpool | Carabao Cup Quarter Final |
| 11 | Thu 26 Dec | 30-1 v West Ham UnitedSouthampton 0-1 West Ham United | Premier League |
| 12 | Sun 29 Dec | 31-2 v Crystal PalaceCrystal Palace 2-1 Southampton | Premier League |
| 13 | Sun 12 Jan | 3 3-0 v Swansea CitySouthampton 3-0 Swansea City | Emirates FA Cup Third Round |
| 14 | Sun 19 Jan | 32-3 v Nottingham ForestNottingham Forest 3-2 Southampton | Premier League |
| 15 | Sat 25 Jan | 31-3 v Newcastle UnitedSouthampton 1-3 Newcastle United | Premier League |
| 16 | Sat 8 Feb | 30-1 v BurnleySouthampton 0-1 Burnley | Emirates FA Cup Fourth Round |
| 17 | Sat 15 Feb | 31-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth | Premier League |
| 18 | Tue 25 Feb | 3 0-4 v ChelseaChelsea 4-0 Southampton | Premier League |
| 19 | Sat 8 Mar | 31-3 v LiverpoolLiverpool 3-1 Southampton | Premier League |
| 20 | Sat 15 Mar | 31-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 21 | Wed 2 Apr | 31-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 22 | Sun 6 Apr | 31-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton | Premier League |
| 23 | Sat 12 Apr | 30-3 v Aston VillaSouthampton 0-3 Aston Villa | Premier League |
| 24 | Sat 19 Apr | 31-1 v West Ham UnitedWest Ham United 1-1 Southampton | Premier League |
| 25 | Sat 26 Apr | 31-2 v FulhamSouthampton 1-2 Fulham | Premier League |
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