| 1 | Sat 17 Aug | 160-1 v Newcastle UnitedNewcastle United 1-0 Southampton | Premier League |
| 2 | Sat 24 Aug | 160-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 3 | Sat 31 Aug | 161-3 v BrentfordBrentford 3-1 Southampton | Premier League |
| 4 | Sat 14 Sep | 160-3 v Manchester UnitedSouthampton 0-3 Manchester United | Premier League |
| 5 | Sat 21 Sep | 161-1 v Ipswich TownSouthampton 1-1 Ipswich Town | Premier League |
| 6 | Mon 30 Sep | 16 1-3 v AFC BournemouthAFC Bournemouth 3-1 Southampton | Premier League |
| 7 | Sat 5 Oct | 161-3 v ArsenalArsenal 3-1 Southampton | Premier League |
| 8 | Sat 19 Oct | 16 2-3 v Leicester CitySouthampton 2-3 Leicester City | Premier League |
| 9 | Tue 29 Oct | 163-2 v Stoke CitySouthampton 3-2 Stoke City | Carabao Cup Round of 16 |
| 10 | Sat 2 Nov | 161-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 11 | Sat 9 Nov | 160-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 12 | Sun 24 Nov | 162-3 v LiverpoolSouthampton 2-3 Liverpool | Premier League |
| 13 | Fri 29 Nov | 161-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Southampton | Premier League |
| 14 | Wed 4 Dec | 161-5 v ChelseaSouthampton 1-5 Chelsea | Premier League |
| 15 | Sun 15 Dec | 160-5 v Tottenham HotspurSouthampton 0-5 Tottenham Hotspur | Premier League |
| 16 | Wed 18 Dec | 161-2 v LiverpoolSouthampton 1-2 Liverpool | Carabao Cup Quarter Final |
| 17 | Sun 22 Dec | 16 0-0 v FulhamFulham 0-0 Southampton | Premier League |
| 18 | Thu 26 Dec | 160-1 v West Ham UnitedSouthampton 0-1 West Ham United | Premier League |
| 19 | Sat 4 Jan | 160-5 v BrentfordSouthampton 0-5 Brentford | Premier League |
| 20 | Thu 16 Jan | 161-3 v Manchester UnitedManchester United 3-1 Southampton | Premier League |
| 21 | Sun 19 Jan | 162-3 v Nottingham ForestNottingham Forest 3-2 Southampton | Premier League |
| 22 | Sat 25 Jan | 161-3 v Newcastle UnitedSouthampton 1-3 Newcastle United | Premier League |
| 23 | Sat 1 Feb | 16 2-1 v Ipswich TownIpswich Town 1-2 Southampton | Premier League |
| 24 | Sat 15 Feb | 161-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth | Premier League |
| 25 | Sat 22 Feb | 160-4 v Brighton & Hove AlbionSouthampton 0-4 Brighton & Hove Albion | Premier League |
| 26 | Tue 25 Feb | 160-4 v ChelseaChelsea 4-0 Southampton | Premier League |
| 27 | Sat 8 Mar | 161-3 v LiverpoolLiverpool 3-1 Southampton | Premier League |
| 28 | Sat 15 Mar | 161-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 29 | Wed 2 Apr | 161-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 30 | Sun 6 Apr | 161-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton | Premier League |
| 31 | Sat 12 Apr | 160-3 v Aston VillaSouthampton 0-3 Aston Villa | Premier League |
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