| 1 | Sun 27 Sep 2020 | 163-1 v CádizCádiz 1-3 Sevilla |
| 2 | Thu 1 Oct 2020 | 16 1-0 v LevanteSevilla 1-0 Levante |
| 3 | Sun 4 Oct 2020 | 161-1 v BarcelonaBarcelona 1-1 Sevilla |
| 4 | Sat 17 Oct 2020 | 160-1 v GranadaGranada 1-0 Sevilla |
| 5 | Sat 24 Oct 2020 | 160-1 v EibarSevilla 0-1 Eibar |
| 6 | Sat 31 Oct 2020 | 16 1-2 v Athletic BilbaoAthletic Bilbao 2-1 Sevilla |
| 7 | Sat 7 Nov 2020 | 161-0 v OsasunaSevilla 1-0 Osasuna |
| 8 | Sat 21 Nov 2020 | 16 4-2 v Celta VigoSevilla 4-2 Celta Vigo |
| 9 | Sat 28 Nov 2020 | 161-0 v HuescaHuesca 0-1 Sevilla |
| 10 | Sat 5 Dec 2020 | 160-1 v Real MadridSevilla 0-1 Real Madrid |
| 11 | Sat 19 Dec 2020 | 161-1 v Real ValladolidSevilla 1-1 Real Valladolid |
| 12 | Tue 22 Dec 2020 | 161-0 v ValenciaValencia 0-1 Sevilla |
| 13 | Tue 29 Dec 2020 | 162-0 v VillarrealSevilla 2-0 Villarreal |
| 14 | Sat 2 Jan 2021 | 161-1 v Real BetisReal Betis 1-1 Sevilla |
| 15 | Sat 9 Jan 2021 | 163-2 v Real SociedadSevilla 3-2 Real Sociedad |
| 16 | Tue 12 Jan 2021 | 160-2 v Atlético MadridAtlético Madrid 2-0 Sevilla |
| 17 | Tue 19 Jan 2021 | 16 2-1 v AlavésAlavés 1-2 Sevilla |
| 18 | Sat 23 Jan 2021 | 163-0 v CádizSevilla 3-0 Cádiz |
| 19 | Sat 30 Jan 2021 | 162-0 v EibarEibar 0-2 Sevilla |
| 20 | Mon 22 Feb 2021 | 162-0 v OsasunaOsasuna 0-2 Sevilla |
| 21 | Sat 27 Feb 2021 | 160-2 v BarcelonaSevilla 0-2 Barcelona |
| 22 | Sat 6 Mar 2021 | 161-2 v ElcheElche 2-1 Sevilla |
| 23 | Sun 14 Mar 2021 | 161-0 v Real BetisSevilla 1-0 Real Betis |
| 24 | Wed 17 Mar 2021 | 162-0 v ElcheSevilla 2-0 Elche |
| 25 | Sat 20 Mar 2021 | 161-1 v Real ValladolidReal Valladolid 1-1 Sevilla |
| 26 | Sun 4 Apr 2021 | 161-0 v Atlético MadridSevilla 1-0 Atlético Madrid |
| 27 | Mon 12 Apr 2021 | 164-3 v Celta VigoCelta Vigo 3-4 Sevilla |
| 28 | Sun 18 Apr 2021 | 162-1 v Real SociedadReal Sociedad 1-2 Sevilla |
| 29 | Wed 21 Apr 2021 | 161-0 v LevanteLevante 0-1 Sevilla |
| 30 | Sun 25 Apr 2021 | 162-1 v GranadaSevilla 2-1 Granada |
| 31 | Mon 3 May 2021 | 160-1 v Athletic BilbaoSevilla 0-1 Athletic Bilbao |
| 32 | Sun 9 May 2021 | 162-2 v Real MadridReal Madrid 2-2 Sevilla |
| 33 | Wed 12 May 2021 | 161-0 v ValenciaSevilla 1-0 Valencia |
| 34 | Sun 16 May 2021 | 160-4 v VillarrealVillarreal 4-0 Sevilla |
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