| 1 | Tue 6 Aug | 61-1 v Steaua BucharestSparta Prague 1-1 Steaua Bucharest | UEFA Champions League Third Qualifying Round |
| 2 | Tue 13 Aug | 63-2 v Steaua BucharestSteaua Bucharest 2-3 Sparta Prague | UEFA Champions League Third Qualifying Round |
| 3 | Wed 21 Aug | 62-0 v Malmö FFMalmö FF 0-2 Sparta Prague | UEFA Champions League Play-off |
| 4 | Tue 27 Aug | 62-0 v Malmö FFSparta Prague 2-0 Malmö FF | UEFA Champions League Play-off |
| 5 | Wed 18 Sep | 63-0 v SV Red Bull SalzburgSparta Prague 3-0 SV Red Bull Salzburg | UEFA Champions League Matchday 1 |
| 6 | Tue 1 Oct | 6 1-1 v VfB StuttgartVfB Stuttgart 1-1 Sparta Prague | UEFA Champions League Matchday 2 |
| 7 | Wed 23 Oct | 60-5 v Manchester CityManchester City 5-0 Sparta Prague | UEFA Champions League Matchday 3 |
| 8 | Wed 6 Nov | 61-2 v BrestSparta Prague 1-2 Brest | UEFA Champions League Matchday 4 |
| 9 | Tue 26 Nov | 60-6 v Atlético MadridSparta Prague 0-6 Atlético Madrid | UEFA Champions League Matchday 5 |
| 10 | Wed 11 Dec | 62-4 v FeyenoordFeyenoord 4-2 Sparta Prague | UEFA Champions League Matchday 6 |
| 11 | Wed 22 Jan | 60-1 v Inter MilanSparta Prague 0-1 Inter Milan | UEFA Champions League Matchday 7 |
| 12 | Wed 29 Jan | 60-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-0 Sparta Prague | UEFA Champions League Matchday 8 |
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