| 1 | Sat 8 Jan 2022 | 214-0 v Scunthorpe UnitedTranmere Rovers 4-0 Scunthorpe United | Sky Bet League Two |
| 2 | Tue 11 Jan 2022 | 211-1 v Salford CitySalford City 1-1 Tranmere Rovers | Sky Bet League Two |
| 3 | Sat 15 Jan 2022 | 212-0 v RochdaleTranmere Rovers 2-0 Rochdale | Sky Bet League Two |
| 4 | Sat 22 Jan 2022 | 211-0 v Crawley TownCrawley Town 0-1 Tranmere Rovers | Sky Bet League Two |
| 5 | Sat 29 Jan 2022 | 210-4 v Forest Green RoversTranmere Rovers 0-4 Forest Green Rovers | Sky Bet League Two |
| 6 | Tue 1 Feb 2022 | 211-0 v StevenageTranmere Rovers 1-0 Stevenage | Sky Bet League Two |
| 7 | Sat 12 Feb 2022 | 210-1 v WalsallWalsall 1-0 Tranmere Rovers | Sky Bet League Two |
| 8 | Sat 19 Feb 2022 | 211-1 v Port ValeTranmere Rovers 1-1 Port Vale | Sky Bet League Two |
| 9 | Sat 5 Mar 2022 | 21 2-3 v Northampton TownNorthampton Town 3-2 Tranmere Rovers | Sky Bet League Two |
| 10 | Fri 11 Mar 2022 | 213-2 v Mansfield TownTranmere Rovers 3-2 Mansfield Town | Sky Bet League Two |
| 11 | Tue 15 Mar 2022 | 21 2-0 v Harrogate TownTranmere Rovers 2-0 Harrogate Town | Sky Bet League Two |
| 12 | Sat 19 Mar 2022 | 211-1 v Sutton UnitedSutton United 1-1 Tranmere Rovers | Sky Bet League Two |
| 13 | Mon 18 Apr 2022 | 212-0 v Exeter CityTranmere Rovers 2-0 Exeter City | Sky Bet League Two |
| 14 | Sat 30 Apr 2022 | 212-0 v Oldham AthleticTranmere Rovers 2-0 Oldham Athletic | Sky Bet League Two |
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