| 1 | Sat 12 Dec 2020 | 160-0 v TrabzonsporKayserispor 0-0 Trabzonspor |
| 2 | Mon 21 Dec 2020 | 160-2 v AntalyasporAntalyaspor 2-0 Kayserispor |
| 3 | Sun 3 Jan 2021 | 160-2 v BeşiktaşKayserispor 0-2 Beşiktaş |
| 4 | Wed 6 Jan 2021 | 16 1-0 v DenizlisporDenizlispor 0-1 Kayserispor |
| 5 | Sat 9 Jan 2021 | 161-0 v Yeni MalatyasporKayserispor 1-0 Yeni Malatyaspor |
| 6 | Sat 16 Jan 2021 | 161-2 v Gazişehir GaziantepGazişehir Gaziantep 2-1 Kayserispor |
| 7 | Tue 19 Jan 2021 | 162-0 v İstanbul BaşakşehirKayserispor 2-0 İstanbul Başakşehir |
| 8 | Mon 25 Jan 2021 | 160-3 v FenerbahçeFenerbahçe 3-0 Kayserispor |
| 9 | Sat 30 Jan 2021 | 161-0 v Kasımpaşa SKKasımpaşa SK 0-1 Kayserispor |
| 10 | Wed 3 Feb 2021 | 16 1-1 v AlanyasporKayserispor 1-1 Alanyaspor |
| 11 | Sun 7 Feb 2021 | 161-1 v BB ErzurumsporBB Erzurumspor 1-1 Kayserispor |
| 12 | Sat 13 Feb 2021 | 160-0 v AnkaragücüKayserispor 0-0 Ankaragücü |
| 13 | Sun 21 Feb 2021 | 160-2 v SivassporSivasspor 2-0 Kayserispor |
| 14 | Wed 3 Mar 2021 | 162-1 v Çaykur RizesporKayserispor 2-1 Çaykur Rizespor |
| 15 | Sun 7 Mar 2021 | 163-1 v HataysporHatayspor 1-3 Kayserispor |
| 16 | Sat 13 Mar 2021 | 160-3 v GalatasarayKayserispor 0-3 Galatasaray |
| 17 | Fri 19 Mar 2021 | 160-3 v Fatih KaragümrükFatih Karagümrük 3-0 Kayserispor |
| 18 | Sat 3 Apr 2021 | 161-1 v Göztepe SKKayserispor 1-1 Göztepe SK |
| 19 | Tue 6 Apr 2021 | 161-1 v TrabzonsporTrabzonspor 1-1 Kayserispor |
| 20 | Sun 11 Apr 2021 | 160-1 v AntalyasporKayserispor 0-1 Antalyaspor |
| 21 | Fri 16 Apr 2021 | 160-0 v KonyasporKonyaspor 0-0 Kayserispor |
| 22 | Tue 20 Apr 2021 | 162-2 v GençlerbirliğiKayserispor 2-2 Gençlerbirliği |
| 23 | Sat 24 Apr 2021 | 161-3 v BeşiktaşBeşiktaş 3-1 Kayserispor |
| 24 | Wed 28 Apr 2021 | 166-3 v DenizlisporKayserispor 6-3 Denizlispor |
| 25 | Mon 3 May 2021 | 161-1 v Yeni MalatyasporYeni Malatyaspor 1-1 Kayserispor |
| 26 | Sat 8 May 2021 | 160-0 v Gazişehir GaziantepKayserispor 0-0 Gazişehir Gaziantep |
| 27 | Tue 11 May 2021 | 160-0 v İstanbul Başakşehirİstanbul Başakşehir 0-0 Kayserispor |
| 28 | Sat 15 May 2021 | 161-2 v FenerbahçeKayserispor 1-2 Fenerbahçe |
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