| 1 | Sat 19 Sep 2020 | 3 0-2 v AlanyasporAlanyaspor 2-0 Kayserispor |
| 2 | Sat 26 Sep 2020 | 31-3 v BB ErzurumsporKayserispor 1-3 BB Erzurumspor |
| 3 | Fri 2 Oct 2020 | 31-0 v AnkaragücüAnkaragücü 0-1 Kayserispor |
| 4 | Sun 1 Nov 2020 | 30-1 v Çaykur RizesporÇaykur Rizespor 1-0 Kayserispor |
| 5 | Sun 8 Nov 2020 | 30-1 v HataysporKayserispor 0-1 Hatayspor |
| 6 | Mon 23 Nov 2020 | 31-1 v GalatasarayGalatasaray 1-1 Kayserispor |
| 7 | Mon 30 Nov 2020 | 30-0 v Fatih KaragümrükKayserispor 0-0 Fatih Karagümrük |
| 8 | Sat 5 Dec 2020 | 31-1 v Göztepe SKGöztepe SK 1-1 Kayserispor |
| 9 | Sat 12 Dec 2020 | 30-0 v TrabzonsporKayserispor 0-0 Trabzonspor |
| 10 | Mon 21 Dec 2020 | 30-2 v AntalyasporAntalyaspor 2-0 Kayserispor |
| 11 | Thu 24 Dec 2020 | 31-2 v KonyasporKayserispor 1-2 Konyaspor |
| 12 | Sat 9 Jan 2021 | 31-0 v Yeni MalatyasporKayserispor 1-0 Yeni Malatyaspor |
| 13 | Sat 16 Jan 2021 | 31-2 v Gazişehir GaziantepGazişehir Gaziantep 2-1 Kayserispor |
| 14 | Tue 19 Jan 2021 | 32-0 v İstanbul BaşakşehirKayserispor 2-0 İstanbul Başakşehir |
| 15 | Mon 25 Jan 2021 | 30-3 v FenerbahçeFenerbahçe 3-0 Kayserispor |
| 16 | Sat 30 Jan 2021 | 31-0 v Kasımpaşa SKKasımpaşa SK 0-1 Kayserispor |
| 17 | Wed 3 Feb 2021 | 31-1 v AlanyasporKayserispor 1-1 Alanyaspor |
| 18 | Wed 3 Mar 2021 | 32-1 v Çaykur RizesporKayserispor 2-1 Çaykur Rizespor |
| 19 | Sun 7 Mar 2021 | 3 3-1 v HataysporHatayspor 1-3 Kayserispor |
| 20 | Sat 13 Mar 2021 | 30-3 v GalatasarayKayserispor 0-3 Galatasaray |
| 21 | Fri 19 Mar 2021 | 30-3 v Fatih KaragümrükFatih Karagümrük 3-0 Kayserispor |
| 22 | Sat 3 Apr 2021 | 31-1 v Göztepe SKKayserispor 1-1 Göztepe SK |
| 23 | Tue 6 Apr 2021 | 31-1 v TrabzonsporTrabzonspor 1-1 Kayserispor |
| 24 | Sun 11 Apr 2021 | 30-1 v AntalyasporKayserispor 0-1 Antalyaspor |
| 25 | Fri 16 Apr 2021 | 30-0 v KonyasporKonyaspor 0-0 Kayserispor |
| 26 | Tue 20 Apr 2021 | 32-2 v GençlerbirliğiKayserispor 2-2 Gençlerbirliği |
| 27 | Sat 24 Apr 2021 | 31-3 v BeşiktaşBeşiktaş 3-1 Kayserispor |
| 28 | Mon 3 May 2021 | 31-1 v Yeni MalatyasporYeni Malatyaspor 1-1 Kayserispor |
| 29 | Sat 8 May 2021 | 3 0-0 v Gazişehir GaziantepKayserispor 0-0 Gazişehir Gaziantep |
| 30 | Tue 11 May 2021 | 30-0 v İstanbul Başakşehirİstanbul Başakşehir 0-0 Kayserispor |
| 31 | Sat 15 May 2021 | 31-2 v FenerbahçeKayserispor 1-2 Fenerbahçe |
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