| 1 | Sun 15 Aug 2021 | 411-0 v Adana DemirsporAdana Demirspor 0-1 Fenerbahçe |
| 2 | Sun 22 Aug 2021 | 412-0 v AntalyasporFenerbahçe 2-0 Antalyaspor |
| 3 | Sun 29 Aug 2021 | 412-0 v AltayAltay 0-2 Fenerbahçe |
| 4 | Sun 12 Sep 2021 | 411-1 v SivassporFenerbahçe 1-1 Sivasspor |
| 5 | Sun 19 Sep 2021 | 410-2 v İstanbul Başakşehirİstanbul Başakşehir 2-0 Fenerbahçe |
| 6 | Thu 23 Sep 2021 | 412-1 v GiresunsporFenerbahçe 2-1 Giresunspor |
| 7 | Sun 26 Sep 2021 | 412-1 v HataysporHatayspor 1-2 Fenerbahçe |
| 8 | Sun 3 Oct 2021 | 412-1 v Kasımpaşa SKFenerbahçe 2-1 Kasımpaşa SK |
| 9 | Sun 17 Oct 2021 | 41 1-3 v TrabzonsporTrabzonspor 3-1 Fenerbahçe |
| 10 | Sun 24 Oct 2021 | 411-2 v AlanyasporFenerbahçe 1-2 Alanyaspor |
| 11 | Sat 30 Oct 2021 | 411-2 v KonyasporKonyaspor 2-1 Fenerbahçe |
| 12 | Sun 7 Nov 2021 | 412-2 v KayserisporFenerbahçe 2-2 Kayserispor |
| 13 | Mon 29 Nov 2021 | 411-1 v Göztepe SKGöztepe SK 1-1 Fenerbahçe |
| 14 | Sun 5 Dec 2021 | 414-0 v Çaykur RizesporFenerbahçe 4-0 Çaykur Rizespor |
| 15 | Mon 13 Dec 2021 | 412-3 v Gazişehir GaziantepGazişehir Gaziantep 3-2 Fenerbahçe |
| 16 | Sun 19 Dec 2021 | 41 2-2 v BeşiktaşFenerbahçe 2-2 Beşiktaş |
| 17 | Wed 22 Dec 2021 | 411-1 v Fatih KaragümrükFatih Karagümrük 1-1 Fenerbahçe |
| 18 | Sun 26 Dec 2021 | 412-0 v Yeni MalatyasporFenerbahçe 2-0 Yeni Malatyaspor |
| 19 | Mon 10 Jan 2022 | 411-2 v Adana DemirsporFenerbahçe 1-2 Adana Demirspor |
| 20 | Wed 19 Jan 2022 | 41 2-1 v AltayFenerbahçe 2-1 Altay |
| 21 | Sat 5 Feb 2022 | 410-1 v İstanbul BaşakşehirFenerbahçe 0-1 İstanbul Başakşehir |
| 22 | Sat 12 Feb 2022 | 41 2-1 v GiresunsporGiresunspor 1-2 Fenerbahçe |
| 23 | Sun 20 Feb 2022 | 412-0 v HataysporFenerbahçe 2-0 Hatayspor |
| 24 | Mon 28 Feb 2022 | 412-1 v Kasımpaşa SKKasımpaşa SK 1-2 Fenerbahçe |
| 25 | Sun 6 Mar 2022 | 411-1 v TrabzonsporFenerbahçe 1-1 Trabzonspor |
| 26 | Sun 13 Mar 2022 | 415-2 v AlanyasporAlanyaspor 2-5 Fenerbahçe |
| 27 | Sun 20 Mar 2022 | 412-1 v KonyasporFenerbahçe 2-1 Konyaspor |
| 28 | Sat 2 Apr 2022 | 414-0 v KayserisporKayserispor 0-4 Fenerbahçe |
| 29 | Sun 10 Apr 2022 | 412-0 v GalatasarayFenerbahçe 2-0 Galatasaray |
| 30 | Sat 16 Apr 2022 | 412-0 v Göztepe SKFenerbahçe 2-0 Göztepe SK |
| 31 | Sat 21 May 2022 | 41 5-0 v Yeni MalatyasporYeni Malatyaspor 0-5 Fenerbahçe |
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