| 1 | Fri 20 Aug 2021 | 671-1 v KayserisporKayserispor 1-1 Adana Demirspor |
| 2 | Fri 27 Aug 2021 | 671-1 v KonyasporAdana Demirspor 1-1 Konyaspor |
| 3 | Sat 18 Sep 2021 | 673-1 v Çaykur RizesporAdana Demirspor 3-1 Çaykur Rizespor |
| 4 | Tue 21 Sep 2021 | 673-3 v BeşiktaşBeşiktaş 3-3 Adana Demirspor |
| 5 | Sat 25 Sep 2021 | 674-0 v Gazişehir GaziantepAdana Demirspor 4-0 Gazişehir Gaziantep |
| 6 | Fri 1 Oct 2021 | 672-1 v AntalyasporAntalyaspor 1-2 Adana Demirspor |
| 7 | Sat 16 Oct 2021 | 670-2 v Yeni MalatyasporAdana Demirspor 0-2 Yeni Malatyaspor |
| 8 | Sun 24 Oct 2021 | 671-1 v SivassporSivasspor 1-1 Adana Demirspor |
| 9 | Mon 1 Nov 2021 | 671-2 v İstanbul Başakşehirİstanbul Başakşehir 2-1 Adana Demirspor |
| 10 | Sun 7 Nov 2021 | 671-0 v HataysporAdana Demirspor 1-0 Hatayspor |
| 11 | Sun 21 Nov 2021 | 673-1 v AltayAltay 1-3 Adana Demirspor |
| 12 | Fri 26 Nov 2021 | 670-0 v Kasımpaşa SKAdana Demirspor 0-0 Kasımpaşa SK |
| 13 | Sat 4 Dec 2021 | 670-2 v TrabzonsporTrabzonspor 2-0 Adana Demirspor |
| 14 | Sat 18 Dec 2021 | 673-1 v AlanyasporAlanyaspor 1-3 Adana Demirspor |
| 15 | Tue 21 Dec 2021 | 67 2-0 v GalatasarayAdana Demirspor 2-0 Galatasaray |
| 16 | Sun 26 Dec 2021 | 671-1 v Göztepe SKGöztepe SK 1-1 Adana Demirspor |
| 17 | Mon 10 Jan 2022 | 672-1 v FenerbahçeFenerbahçe 1-2 Adana Demirspor |
| 18 | Sat 15 Jan 2022 | 671-1 v KayserisporAdana Demirspor 1-1 Kayserispor |
| 19 | Tue 18 Jan 2022 | 670-1 v KonyasporKonyaspor 1-0 Adana Demirspor |
| 20 | Sat 22 Jan 2022 | 675-0 v Fatih KaragümrükAdana Demirspor 5-0 Fatih Karagümrük |
| 21 | Sun 6 Feb 2022 | 67 3-1 v Çaykur RizesporÇaykur Rizespor 1-3 Adana Demirspor |
| 22 | Mon 14 Feb 2022 | 671-1 v BeşiktaşAdana Demirspor 1-1 Beşiktaş |
| 23 | Sun 20 Feb 2022 | 673-0 v Gazişehir GaziantepGazişehir Gaziantep 0-3 Adana Demirspor |
| 24 | Fri 25 Feb 2022 | 670-0 v AntalyasporAdana Demirspor 0-0 Antalyaspor |
| 25 | Fri 4 Mar 2022 | 670-1 v Yeni MalatyasporYeni Malatyaspor 1-0 Adana Demirspor |
| 26 | Sun 13 Mar 2022 | 672-3 v SivassporAdana Demirspor 2-3 Sivasspor |
| 27 | Sat 19 Mar 2022 | 672-1 v İstanbul BaşakşehirAdana Demirspor 2-1 İstanbul Başakşehir |
| 28 | Mon 4 Apr 2022 | 670-0 v HataysporHatayspor 0-0 Adana Demirspor |
| 29 | Sat 23 Apr 2022 | 671-3 v TrabzonsporAdana Demirspor 1-3 Trabzonspor |
| 30 | Fri 29 Apr 2022 | 670-2 v GiresunsporGiresunspor 2-0 Adana Demirspor |
| 31 | Sat 7 May 2022 | 671-2 v AlanyasporAdana Demirspor 1-2 Alanyaspor |
| 32 | Mon 16 May 2022 | 672-3 v GalatasarayGalatasaray 3-2 Adana Demirspor |
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