| 1 | Mon 16 Aug 2021 | 240-2 v GalatasarayGiresunspor 0-2 Galatasaray |
| 2 | Sat 21 Aug 2021 | 240-2 v Kasımpaşa SKKasımpaşa SK 2-0 Giresunspor |
| 3 | Sun 29 Aug 2021 | 240-1 v TrabzonsporGiresunspor 0-1 Trabzonspor |
| 4 | Mon 13 Sep 2021 | 240-1 v AlanyasporAlanyaspor 1-0 Giresunspor |
| 5 | Sun 19 Sep 2021 | 240-0 v KonyasporGiresunspor 0-0 Konyaspor |
| 6 | Thu 23 Sep 2021 | 241-2 v FenerbahçeFenerbahçe 2-1 Giresunspor |
| 7 | Sun 26 Sep 2021 | 241-1 v KayserisporGiresunspor 1-1 Kayserispor |
| 8 | Sat 2 Oct 2021 | 241-0 v Göztepe SKGöztepe SK 0-1 Giresunspor |
| 9 | Sat 16 Oct 2021 | 242-0 v Çaykur RizesporGiresunspor 2-0 Çaykur Rizespor |
| 10 | Sat 23 Oct 2021 | 241-1 v Gazişehir GaziantepGazişehir Gaziantep 1-1 Giresunspor |
| 11 | Mon 1 Nov 2021 | 241-2 v AntalyasporGiresunspor 1-2 Antalyaspor |
| 12 | Sat 6 Nov 2021 | 240-0 v SivassporSivasspor 0-0 Giresunspor |
| 13 | Sat 20 Nov 2021 | 241-0 v Yeni MalatyasporGiresunspor 1-0 Yeni Malatyaspor |
| 14 | Sat 27 Nov 2021 | 244-0 v BeşiktaşBeşiktaş 0-4 Giresunspor |
| 15 | Sun 5 Dec 2021 | 243-1 v Fatih KaragümrükGiresunspor 3-1 Fatih Karagümrük |
| 16 | Sun 12 Dec 2021 | 240-1 v Adana DemirsporAdana Demirspor 1-0 Giresunspor |
| 17 | Tue 21 Dec 2021 | 241-3 v İstanbul Başakşehirİstanbul Başakşehir 3-1 Giresunspor |
| 18 | Sat 25 Dec 2021 | 240-1 v HataysporGiresunspor 0-1 Hatayspor |
| 19 | Sat 8 Jan 2022 | 241-0 v GalatasarayGalatasaray 0-1 Giresunspor |
| 20 | Sun 16 Jan 2022 | 240-2 v Kasımpaşa SKGiresunspor 0-2 Kasımpaşa SK |
| 21 | Wed 19 Jan 2022 | 241-1 v TrabzonsporTrabzonspor 1-1 Giresunspor |
| 22 | Sun 23 Jan 2022 | 241-3 v AlanyasporGiresunspor 1-3 Alanyaspor |
| 23 | Fri 4 Feb 2022 | 240-1 v KonyasporKonyaspor 1-0 Giresunspor |
| 24 | Sat 12 Feb 2022 | 241-2 v FenerbahçeGiresunspor 1-2 Fenerbahçe |
| 25 | Sat 19 Feb 2022 | 241-2 v KayserisporKayserispor 2-1 Giresunspor |
| 26 | Sun 27 Feb 2022 | 243-1 v Göztepe SKGiresunspor 3-1 Göztepe SK |
| 27 | Sat 5 Mar 2022 | 242-1 v Çaykur RizesporÇaykur Rizespor 1-2 Giresunspor |
| 28 | Mon 14 Mar 2022 | 242-1 v Gazişehir GaziantepGiresunspor 2-1 Gazişehir Gaziantep |
| 29 | Sat 2 Apr 2022 | 242-2 v SivassporGiresunspor 2-2 Sivasspor |
| 30 | Sun 10 Apr 2022 | 241-0 v Yeni MalatyasporYeni Malatyaspor 0-1 Giresunspor |
| 31 | Sun 17 Apr 2022 | 240-0 v BeşiktaşGiresunspor 0-0 Beşiktaş |
| 32 | Sat 23 Apr 2022 | 241-2 v Fatih KaragümrükFatih Karagümrük 2-1 Giresunspor |
| 33 | Fri 29 Apr 2022 | 242-0 v Adana DemirsporGiresunspor 2-0 Adana Demirspor |
| 34 | Sun 8 May 2022 | 241-1 v AltayAltay 1-1 Giresunspor |
| 35 | Sun 15 May 2022 | 241-1 v İstanbul BaşakşehirGiresunspor 1-1 İstanbul Başakşehir |
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