| 1 | Sat 18 Sep 2021 | 913-1 v Çaykur RizesporAdana Demirspor 3-1 Çaykur Rizespor |
| 2 | Tue 21 Sep 2021 | 91 3-3 v BeşiktaşBeşiktaş 3-3 Adana Demirspor |
| 3 | Sat 25 Sep 2021 | 914-0 v Gazişehir GaziantepAdana Demirspor 4-0 Gazişehir Gaziantep |
| 4 | Fri 1 Oct 2021 | 912-1 v AntalyasporAntalyaspor 1-2 Adana Demirspor |
| 5 | Sat 16 Oct 2021 | 910-2 v Yeni MalatyasporAdana Demirspor 0-2 Yeni Malatyaspor |
| 6 | Sun 24 Oct 2021 | 911-1 v SivassporSivasspor 1-1 Adana Demirspor |
| 7 | Mon 1 Nov 2021 | 911-2 v İstanbul Başakşehirİstanbul Başakşehir 2-1 Adana Demirspor |
| 8 | Sun 7 Nov 2021 | 911-0 v HataysporAdana Demirspor 1-0 Hatayspor |
| 9 | Sun 21 Nov 2021 | 913-1 v AltayAltay 1-3 Adana Demirspor |
| 10 | Fri 26 Nov 2021 | 910-0 v Kasımpaşa SKAdana Demirspor 0-0 Kasımpaşa SK |
| 11 | Sat 4 Dec 2021 | 910-2 v TrabzonsporTrabzonspor 2-0 Adana Demirspor |
| 12 | Sun 12 Dec 2021 | 911-0 v GiresunsporAdana Demirspor 1-0 Giresunspor |
| 13 | Sat 18 Dec 2021 | 913-1 v AlanyasporAlanyaspor 1-3 Adana Demirspor |
| 14 | Tue 21 Dec 2021 | 912-0 v GalatasarayAdana Demirspor 2-0 Galatasaray |
| 15 | Sun 26 Dec 2021 | 911-1 v Göztepe SKGöztepe SK 1-1 Adana Demirspor |
| 16 | Sun 6 Feb 2022 | 913-1 v Çaykur RizesporÇaykur Rizespor 1-3 Adana Demirspor |
| 17 | Sat 23 Apr 2022 | 91 1-3 v TrabzonsporAdana Demirspor 1-3 Trabzonspor |
| 18 | Mon 16 May 2022 | 912-3 v GalatasarayGalatasaray 3-2 Adana Demirspor |
| 19 | Sun 22 May 2022 | 917-0 v Göztepe SKAdana Demirspor 7-0 Göztepe SK |
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