| 1 | Sun 15 Aug 2021 | 80-1 v FenerbahçeAdana Demirspor 0-1 Fenerbahçe |
| 2 | Fri 20 Aug 2021 | 81-1 v KayserisporKayserispor 1-1 Adana Demirspor |
| 3 | Fri 27 Aug 2021 | 81-1 v KonyasporAdana Demirspor 1-1 Konyaspor |
| 4 | Sat 11 Sep 2021 | 80-4 v Fatih KaragümrükFatih Karagümrük 4-0 Adana Demirspor |
| 5 | Sat 18 Sep 2021 | 83-1 v Çaykur RizesporAdana Demirspor 3-1 Çaykur Rizespor |
| 6 | Tue 21 Sep 2021 | 83-3 v BeşiktaşBeşiktaş 3-3 Adana Demirspor |
| 7 | Sat 25 Sep 2021 | 84-0 v Gazişehir GaziantepAdana Demirspor 4-0 Gazişehir Gaziantep |
| 8 | Fri 1 Oct 2021 | 82-1 v AntalyasporAntalyaspor 1-2 Adana Demirspor |
| 9 | Sun 24 Oct 2021 | 81-1 v SivassporSivasspor 1-1 Adana Demirspor |
| 10 | Mon 1 Nov 2021 | 81-2 v İstanbul Başakşehirİstanbul Başakşehir 2-1 Adana Demirspor |
| 11 | Sun 7 Nov 2021 | 81-0 v HataysporAdana Demirspor 1-0 Hatayspor |
| 12 | Sun 21 Nov 2021 | 83-1 v AltayAltay 1-3 Adana Demirspor |
| 13 | Fri 26 Nov 2021 | 80-0 v Kasımpaşa SKAdana Demirspor 0-0 Kasımpaşa SK |
| 14 | Sat 4 Dec 2021 | 80-2 v TrabzonsporTrabzonspor 2-0 Adana Demirspor |
| 15 | Sun 12 Dec 2021 | 81-0 v GiresunsporAdana Demirspor 1-0 Giresunspor |
| 16 | Tue 21 Dec 2021 | 82-0 v GalatasarayAdana Demirspor 2-0 Galatasaray |
| 17 | Mon 10 Jan 2022 | 82-1 v FenerbahçeFenerbahçe 1-2 Adana Demirspor |
| 18 | Sat 15 Jan 2022 | 81-1 v KayserisporAdana Demirspor 1-1 Kayserispor |
| 19 | Tue 18 Jan 2022 | 80-1 v KonyasporKonyaspor 1-0 Adana Demirspor |
| 20 | Sun 6 Feb 2022 | 83-1 v Çaykur RizesporÇaykur Rizespor 1-3 Adana Demirspor |
| 21 | Sun 20 Feb 2022 | 83-0 v Gazişehir GaziantepGazişehir Gaziantep 0-3 Adana Demirspor |
| 22 | Sun 13 Mar 2022 | 82-3 v SivassporAdana Demirspor 2-3 Sivasspor |
| 23 | Mon 4 Apr 2022 | 8 0-0 v HataysporHatayspor 0-0 Adana Demirspor |
| 24 | Fri 29 Apr 2022 | 80-2 v GiresunsporGiresunspor 2-0 Adana Demirspor |
| 25 | Sat 7 May 2022 | 81-2 v AlanyasporAdana Demirspor 1-2 Alanyaspor |
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