| 1 | Sun 15 Aug 2021 | 2 0-1 v FenerbahçeAdana Demirspor 0-1 Fenerbahçe |
| 2 | Fri 20 Aug 2021 | 21-1 v KayserisporKayserispor 1-1 Adana Demirspor |
| 3 | Fri 27 Aug 2021 | 21-1 v KonyasporAdana Demirspor 1-1 Konyaspor |
| 4 | Sat 11 Sep 2021 | 20-4 v Fatih KaragümrükFatih Karagümrük 4-0 Adana Demirspor |
| 5 | Sat 18 Dec 2021 | 23-1 v AlanyasporAlanyaspor 1-3 Adana Demirspor |
| 6 | Tue 21 Dec 2021 | 22-0 v GalatasarayAdana Demirspor 2-0 Galatasaray |
| 7 | Sun 26 Dec 2021 | 21-1 v Göztepe SKGöztepe SK 1-1 Adana Demirspor |
| 8 | Mon 10 Jan 2022 | 22-1 v FenerbahçeFenerbahçe 1-2 Adana Demirspor |
| 9 | Sat 15 Jan 2022 | 21-1 v KayserisporAdana Demirspor 1-1 Kayserispor |
| 10 | Tue 18 Jan 2022 | 20-1 v KonyasporKonyaspor 1-0 Adana Demirspor |
| 11 | Sat 22 Jan 2022 | 25-0 v Fatih KaragümrükAdana Demirspor 5-0 Fatih Karagümrük |
| 12 | Sun 6 Feb 2022 | 2 3-1 v Çaykur RizesporÇaykur Rizespor 1-3 Adana Demirspor |
| 13 | Mon 14 Feb 2022 | 21-1 v BeşiktaşAdana Demirspor 1-1 Beşiktaş |
| 14 | Sun 20 Feb 2022 | 23-0 v Gazişehir GaziantepGazişehir Gaziantep 0-3 Adana Demirspor |
| 15 | Fri 25 Feb 2022 | 20-0 v AntalyasporAdana Demirspor 0-0 Antalyaspor |
| 16 | Fri 4 Mar 2022 | 20-1 v Yeni MalatyasporYeni Malatyaspor 1-0 Adana Demirspor |
| 17 | Sun 13 Mar 2022 | 2 2-3 v SivassporAdana Demirspor 2-3 Sivasspor |
| 18 | Sat 19 Mar 2022 | 22-1 v İstanbul BaşakşehirAdana Demirspor 2-1 İstanbul Başakşehir |
| 19 | Mon 4 Apr 2022 | 20-0 v HataysporHatayspor 0-0 Adana Demirspor |
| 20 | Sun 10 Apr 2022 | 23-1 v AltayAdana Demirspor 3-1 Altay |
| 21 | Sun 17 Apr 2022 | 20-4 v Kasımpaşa SKKasımpaşa SK 4-0 Adana Demirspor |
| 22 | Sat 23 Apr 2022 | 21-3 v TrabzonsporAdana Demirspor 1-3 Trabzonspor |
| 23 | Fri 29 Apr 2022 | 20-2 v GiresunsporGiresunspor 2-0 Adana Demirspor |
| 24 | Sat 7 May 2022 | 21-2 v AlanyasporAdana Demirspor 1-2 Alanyaspor |
| 25 | Mon 16 May 2022 | 22-3 v GalatasarayGalatasaray 3-2 Adana Demirspor |
| 26 | Sun 22 May 2022 | 27-0 v Göztepe SKAdana Demirspor 7-0 Göztepe SK |
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