| 1 | Sat 14 Aug 2021 | 41-0 v VfL BochumVfL Wolfsburg 1-0 VfL Bochum | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 42-1 v Hertha BerlinHertha Berlin 1-2 VfL Wolfsburg | German Bundesliga |
| 3 | Sun 29 Aug 2021 | 41-0 v RB LeipzigVfL Wolfsburg 1-0 RB Leipzig | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 42-0 v Greuther FürthGreuther Fürth 0-2 VfL Wolfsburg | German Bundesliga |
| 5 | Tue 14 Sep 2021 | 4 0-0 v LilleLille 0-0 VfL Wolfsburg | UEFA Champions League Group G |
| 6 | Sun 19 Sep 2021 | 41-1 v Eintracht FrankfurtVfL Wolfsburg 1-1 Eintracht Frankfurt | German Bundesliga |
| 7 | Sat 25 Sep 2021 | 41-3 v 1899 Hoffenheim1899 Hoffenheim 3-1 VfL Wolfsburg | German Bundesliga |
| 8 | Wed 29 Sep 2021 | 4 1-1 v SevillaVfL Wolfsburg 1-1 Sevilla | UEFA Champions League Group G |
| 9 | Sat 2 Oct 2021 | 4 1-3 v Borussia MönchengladbachVfL Wolfsburg 1-3 Borussia Mönchengladbach | German Bundesliga |
| 10 | Wed 20 Oct 2021 | 41-3 v SV Red Bull SalzburgSV Red Bull Salzburg 3-1 VfL Wolfsburg | UEFA Champions League Group G |
| 11 | Sat 23 Oct 2021 | 40-2 v SC FreiburgVfL Wolfsburg 0-2 SC Freiburg | German Bundesliga |
| 12 | Sat 30 Oct 2021 | 4 2-0 v Bayer 04 LeverkusenBayer 04 Leverkusen 0-2 VfL Wolfsburg | German Bundesliga |
| 13 | Tue 2 Nov 2021 | 42-1 v SV Red Bull SalzburgVfL Wolfsburg 2-1 SV Red Bull Salzburg | UEFA Champions League Group G |
| 14 | Tue 23 Nov 2021 | 40-2 v SevillaSevilla 2-0 VfL Wolfsburg | UEFA Champions League Group G |
| 15 | Sat 27 Nov 2021 | 4 1-3 v Borussia DortmundVfL Wolfsburg 1-3 Borussia Dortmund | German Bundesliga |
| 16 | Sat 4 Dec 2021 | 40-3 v Mainz 05Mainz 05 3-0 VfL Wolfsburg | German Bundesliga |
| 17 | Wed 8 Dec 2021 | 41-3 v LilleVfL Wolfsburg 1-3 Lille | UEFA Champions League Group G |
| 18 | Sat 11 Dec 2021 | 40-2 v VfB StuttgartVfL Wolfsburg 0-2 VfB Stuttgart | German Bundesliga |
| 19 | Tue 14 Dec 2021 | 42-3 v 1. FC KölnVfL Wolfsburg 2-3 1. FC Köln | German Bundesliga |
| 20 | Fri 17 Dec 2021 | 40-4 v Bayern MunichBayern Munich 4-0 VfL Wolfsburg | German Bundesliga |
| 21 | Sun 9 Jan 2022 | 40-1 v VfL BochumVfL Bochum 1-0 VfL Wolfsburg | German Bundesliga |
| 22 | Sat 15 Jan 2022 | 40-0 v Hertha BerlinVfL Wolfsburg 0-0 Hertha Berlin | German Bundesliga |
| 23 | Sun 23 Jan 2022 | 4 0-2 v RB LeipzigRB Leipzig 2-0 VfL Wolfsburg | German Bundesliga |
| 24 | Sun 6 Feb 2022 | 44-1 v Greuther FürthVfL Wolfsburg 4-1 Greuther Fürth | German Bundesliga |
| 25 | Sat 12 Feb 2022 | 42-0 v Eintracht FrankfurtEintracht Frankfurt 0-2 VfL Wolfsburg | German Bundesliga |
| 26 | Sat 19 Feb 2022 | 41-2 v 1899 HoffenheimVfL Wolfsburg 1-2 1899 Hoffenheim | German Bundesliga |
| 27 | Sat 26 Feb 2022 | 4 2-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-2 VfL Wolfsburg | German Bundesliga |
| 28 | Sat 12 Mar 2022 | 42-3 v SC FreiburgSC Freiburg 3-2 VfL Wolfsburg | German Bundesliga |
| 29 | Sun 20 Mar 2022 | 4 0-2 v Bayer 04 LeverkusenVfL Wolfsburg 0-2 Bayer 04 Leverkusen | German Bundesliga |
| 30 | Sun 3 Apr 2022 | 40-3 v FC AugsburgFC Augsburg 3-0 VfL Wolfsburg | German Bundesliga |
| 31 | Sat 9 Apr 2022 | 44-0 v Arminia BielefeldVfL Wolfsburg 4-0 Arminia Bielefeld | German Bundesliga |
| 32 | Sat 16 Apr 2022 | 41-6 v Borussia DortmundBorussia Dortmund 6-1 VfL Wolfsburg | German Bundesliga |
| 33 | Sat 30 Apr 2022 | 41-1 v VfB StuttgartVfB Stuttgart 1-1 VfL Wolfsburg | German Bundesliga |
| 34 | Sat 7 May 2022 | 41-0 v 1. FC Köln1. FC Köln 0-1 VfL Wolfsburg | German Bundesliga |
| 35 | Sat 14 May 2022 | 42-2 v Bayern MunichVfL Wolfsburg 2-2 Bayern Munich | German Bundesliga |
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