| 1 | Tue 14 Sep 2021 | 42-2 v AtalantaVillarreal 2-2 Atalanta | UEFA Champions League Group F |
| 2 | Sun 19 Sep 2021 | 40-0 v MallorcaMallorca 0-0 Villarreal | Spanish La Liga |
| 3 | Wed 22 Sep 2021 | 44-1 v ElcheVillarreal 4-1 Elche | Spanish La Liga |
| 4 | Sat 25 Sep 2021 | 40-0 v Real MadridReal Madrid 0-0 Villarreal | Spanish La Liga |
| 5 | Wed 29 Sep 2021 | 41-2 v Manchester UnitedManchester United 2-1 Villarreal | UEFA Champions League Group F |
| 6 | Sun 3 Oct 2021 | 4 2-0 v Real BetisVillarreal 2-0 Real Betis | Spanish La Liga |
| 7 | Sun 17 Oct 2021 | 41-2 v OsasunaVillarreal 1-2 Osasuna | Spanish La Liga |
| 8 | Wed 20 Oct 2021 | 44-1 v Young BoysYoung Boys 1-4 Villarreal | UEFA Champions League Group F |
| 9 | Sat 23 Oct 2021 | 41-2 v Athletic BilbaoAthletic Bilbao 2-1 Villarreal | Spanish La Liga |
| 10 | Tue 26 Oct 2021 | 43-3 v CádizVillarreal 3-3 Cádiz | Spanish La Liga |
| 11 | Sat 30 Oct 2021 | 40-2 v ValenciaValencia 2-0 Villarreal | Spanish La Liga |
| 12 | Tue 2 Nov 2021 | 42-0 v Young BoysVillarreal 2-0 Young Boys | UEFA Champions League Group F |
| 13 | Sun 7 Nov 2021 | 41-0 v GetafeVillarreal 1-0 Getafe | Spanish La Liga |
| 14 | Sat 20 Nov 2021 | 41-1 v Celta VigoCelta Vigo 1-1 Villarreal | Spanish La Liga |
| 15 | Tue 23 Nov 2021 | 40-2 v Manchester UnitedVillarreal 0-2 Manchester United | UEFA Champions League Group F |
| 16 | Sat 27 Nov 2021 | 41-3 v BarcelonaVillarreal 1-3 Barcelona | Spanish La Liga |
| 17 | Sat 4 Dec 2021 | 40-1 v SevillaSevilla 1-0 Villarreal | Spanish La Liga |
| 18 | Thu 9 Dec 2021 | 43-2 v AtalantaAtalanta 2-3 Villarreal | UEFA Champions League Group F |
| 19 | Sun 12 Dec 2021 | 4 2-0 v Rayo VallecanoVillarreal 2-0 Rayo Vallecano | Spanish La Liga |
| 20 | Sat 18 Dec 2021 | 4 3-1 v Real SociedadReal Sociedad 1-3 Villarreal | Spanish La Liga |
| 21 | Tue 21 Dec 2021 | 45-2 v AlavésVillarreal 5-2 Alavés | Spanish La Liga |
| 22 | Mon 3 Jan 2022 | 45-0 v LevanteVillarreal 5-0 Levante | Spanish La Liga |
| 23 | Sun 9 Jan 2022 | 42-2 v Atlético MadridVillarreal 2-2 Atlético Madrid | Spanish La Liga |
| 24 | Sun 16 Jan 2022 | 40-1 v ElcheElche 1-0 Villarreal | Spanish La Liga |
| 25 | Sat 22 Jan 2022 | 43-0 v MallorcaVillarreal 3-0 Mallorca | Spanish La Liga |
| 26 | Sun 6 Feb 2022 | 42-0 v Real BetisReal Betis 0-2 Villarreal | Spanish La Liga |
| 27 | Sat 12 Feb 2022 | 40-0 v Real MadridVillarreal 0-0 Real Madrid | Spanish La Liga |
| 28 | Sat 19 Feb 2022 | 44-1 v GranadaGranada 1-4 Villarreal | Spanish La Liga |
| 29 | Tue 22 Feb 2022 | 41-1 v JuventusVillarreal 1-1 Juventus | UEFA Champions League Round of 16 |
| 30 | Sun 27 Feb 2022 | 45-1 v EspanyolVillarreal 5-1 Espanyol | Spanish La Liga |
| 31 | Sat 5 Mar 2022 | 40-1 v OsasunaOsasuna 1-0 Villarreal | Spanish La Liga |
| 32 | Sat 12 Mar 2022 | 41-0 v Celta VigoVillarreal 1-0 Celta Vigo | Spanish La Liga |
| 33 | Wed 16 Mar 2022 | 43-0 v JuventusJuventus 0-3 Villarreal | UEFA Champions League Round of 16 |
| 34 | Sun 20 Mar 2022 | 4 0-1 v CádizCádiz 1-0 Villarreal | Spanish La Liga |
| 35 | Sat 2 Apr 2022 | 4 0-2 v LevanteLevante 2-0 Villarreal | Spanish La Liga |
| 36 | Wed 6 Apr 2022 | 41-0 v Bayern MunichVillarreal 1-0 Bayern Munich | UEFA Champions League Quarter Final |
| 37 | Tue 12 Apr 2022 | 41-1 v Bayern MunichBayern Munich 1-1 Villarreal | UEFA Champions League Quarter Final |
| 38 | Sat 16 Apr 2022 | 42-1 v GetafeGetafe 1-2 Villarreal | Spanish La Liga |
| 39 | Wed 27 Apr 2022 | 40-2 v LiverpoolLiverpool 2-0 Villarreal | UEFA Champions League Semi Final |
| 40 | Sat 30 Apr 2022 | 41-2 v AlavésAlavés 2-1 Villarreal | Spanish La Liga |
| 41 | Tue 3 May 2022 | 4 2-3 v LiverpoolVillarreal 2-3 Liverpool | UEFA Champions League Semi Final |
| 42 | Sun 8 May 2022 | 41-1 v SevillaVillarreal 1-1 Sevilla | Spanish La Liga |
| 43 | Thu 12 May 2022 | 45-1 v Rayo VallecanoRayo Vallecano 1-5 Villarreal | Spanish La Liga |
| 44 | Sun 15 May 2022 | 41-2 v Real SociedadVillarreal 1-2 Real Sociedad | Spanish La Liga |
| 45 | Sun 22 May 2022 | 42-0 v BarcelonaBarcelona 0-2 Villarreal | Spanish La Liga |
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