| 1 | Sun 12 Sep 2021 | 32-1 v RKC WaalwijkRKC Waalwijk 1-2 Vitesse | Dutch Eredivisie |
| 2 | Thu 16 Sep 2021 | 32-0 v Mura Murska SobotaMura Murska Sobota 0-2 Vitesse | UEFA Europa Conference League |
| 3 | Sun 19 Sep 2021 | 3 1-4 v FC TwenteVitesse 1-4 FC Twente | Dutch Eredivisie |
| 4 | Sat 25 Sep 2021 | 31-1 v Fortuna SittardVitesse 1-1 Fortuna Sittard | Dutch Eredivisie |
| 5 | Thu 30 Sep 2021 | 31-2 v RennesVitesse 1-2 Rennes | UEFA Europa Conference League |
| 6 | Sun 3 Oct 2021 | 32-1 v FeyenoordVitesse 2-1 Feyenoord | Dutch Eredivisie |
| 7 | Sun 17 Oct 2021 | 31-0 v NEC NijmegenNEC Nijmegen 0-1 Vitesse | Dutch Eredivisie |
| 8 | Thu 21 Oct 2021 | 31-0 v Tottenham HotspurVitesse 1-0 Tottenham Hotspur | UEFA Europa Conference League |
| 9 | Sun 24 Oct 2021 | 31-2 v Go Ahead EaglesVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 10 | Sat 30 Oct 2021 | 32-1 v sc Heerenveensc Heerenveen 1-2 Vitesse | Dutch Eredivisie |
| 11 | Thu 4 Nov 2021 | 3 2-3 v Tottenham HotspurTottenham Hotspur 3-2 Vitesse | UEFA Europa Conference League |
| 12 | Sun 7 Nov 2021 | 32-1 v FC UtrechtVitesse 2-1 FC Utrecht | Dutch Eredivisie |
| 13 | Sat 20 Nov 2021 | 30-2 v PSV EindhovenPSV Eindhoven 2-0 Vitesse | Dutch Eredivisie |
| 14 | Sun 28 Nov 2021 | 30-0 v AZ AlkmaarVitesse 0-0 AZ Alkmaar | Dutch Eredivisie |
| 15 | Thu 9 Dec 2021 | 3 3-1 v Mura Murska SobotaVitesse 3-1 Mura Murska Sobota | UEFA Europa Conference League |
| 16 | Sun 12 Dec 2021 | 32-1 v Heracles AlmeloVitesse 2-1 Heracles Almelo | Dutch Eredivisie |
| 17 | Sat 18 Dec 2021 | 32-2 v Sparta RotterdamSparta Rotterdam 2-2 Vitesse | Dutch Eredivisie |
| 18 | Tue 21 Dec 2021 | 31-0 v PEC ZwolleVitesse 1-0 PEC Zwolle | Dutch Eredivisie |
| 19 | Sat 15 Jan 2022 | 31-0 v FeyenoordFeyenoord 0-1 Vitesse | Dutch Eredivisie |
| 20 | Sat 22 Jan 2022 | 31-3 v FC GroningenVitesse 1-3 FC Groningen | Dutch Eredivisie |
| 21 | Sat 5 Feb 2022 | 3 0-3 v FC TwenteFC Twente 3-0 Vitesse | Dutch Eredivisie |
| 22 | Sat 12 Feb 2022 | 30-5 v PSV EindhovenVitesse 0-5 PSV Eindhoven | Dutch Eredivisie |
| 23 | Thu 17 Feb 2022 | 3 1-2 v Rapid ViennaRapid Vienna 2-1 Vitesse | UEFA Europa Conference League |
| 24 | Sun 20 Feb 2022 | 31-1 v FC UtrechtFC Utrecht 1-1 Vitesse | Dutch Eredivisie |
| 25 | Thu 24 Feb 2022 | 32-0 v Rapid ViennaVitesse 2-0 Rapid Vienna | UEFA Europa Conference League |
| 26 | Sun 27 Feb 2022 | 34-1 v NEC NijmegenVitesse 4-1 NEC Nijmegen | Dutch Eredivisie |
| 27 | Thu 10 Mar 2022 | 30-1 v RomaVitesse 0-1 Roma | UEFA Europa Conference League Round of 16 |
| 28 | Thu 17 Mar 2022 | 31-1 v RomaRoma 1-1 Vitesse | UEFA Europa Conference League Round of 16 |
| 29 | Sun 20 Mar 2022 | 31-2 v RKC WaalwijkVitesse 1-2 RKC Waalwijk | Dutch Eredivisie |
| 30 | Sat 2 Apr 2022 | 31-3 v AZ AlkmaarAZ Alkmaar 3-1 Vitesse | Dutch Eredivisie |
| 31 | Tue 19 Apr 2022 | 30-1 v Sparta RotterdamVitesse 0-1 Sparta Rotterdam | Dutch Eredivisie |
| 32 | Sun 24 Apr 2022 | 30-1 v Willem IIWillem II 1-0 Vitesse | Dutch Eredivisie |
| 33 | Sun 1 May 2022 | 32-1 v Go Ahead EaglesGo Ahead Eagles 1-2 Vitesse | Dutch Eredivisie |
| 34 | Sun 8 May 2022 | 31-2 v sc HeerenveenVitesse 1-2 sc Heerenveen | Dutch Eredivisie |
| 35 | Wed 11 May 2022 | 3 2-1 v Fortuna SittardFortuna Sittard 1-2 Vitesse | Dutch Eredivisie |
| 36 | Sun 15 May 2022 | 32-2 v AjaxVitesse 2-2 Ajax | Dutch Eredivisie |
| 37 | Thu 19 May 2022 | 3 1-3 v FC UtrechtFC Utrecht 3-1 Vitesse | Dutch Eredivisie Play-off |
| 38 | Sun 22 May 2022 | 33-0 v FC UtrechtVitesse 3-0 FC Utrecht | Dutch Eredivisie Play-off |
| 39 | Thu 26 May 2022 | 32-1 v AZ AlkmaarVitesse 2-1 AZ Alkmaar | Dutch Eredivisie Play-off |
| 40 | Sun 29 May 2022 | 31-6 v AZ AlkmaarAZ Alkmaar 6-1 Vitesse | Dutch Eredivisie Play-off |
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