| 1 | Sun 15 Aug 2021 | 14-2 v Newcastle UnitedNewcastle United 2-4 West Ham United | Premier League |
| 2 | Mon 23 Aug 2021 | 14-1 v Leicester CityWest Ham United 4-1 Leicester City | Premier League |
| 3 | Sat 28 Aug 2021 | 12-2 v Crystal PalaceWest Ham United 2-2 Crystal Palace | Premier League |
| 4 | Sat 11 Sep 2021 | 10-0 v SouthamptonSouthampton 0-0 West Ham United | Premier League |
| 5 | Thu 16 Sep 2021 | 12-0 v Dinamo ZagrebDinamo Zagreb 0-2 West Ham United | UEFA Europa League Group H |
| 6 | Sun 19 Sep 2021 | 11-2 v Manchester UnitedWest Ham United 1-2 Manchester United | Premier League |
| 7 | Sat 25 Sep 2021 | 12-1 v Leeds UnitedLeeds United 1-2 West Ham United | Premier League |
| 8 | Sun 3 Oct 2021 | 11-2 v BrentfordWest Ham United 1-2 Brentford | Premier League |
| 9 | Sun 17 Oct 2021 | 11-0 v EvertonEverton 0-1 West Ham United | Premier League |
| 10 | Sun 24 Oct 2021 | 11-0 v Tottenham HotspurWest Ham United 1-0 Tottenham Hotspur | Premier League |
| 11 | Sun 31 Oct 2021 | 14-1 v Aston VillaAston Villa 1-4 West Ham United | Premier League |
| 12 | Sun 7 Nov 2021 | 13-2 v LiverpoolWest Ham United 3-2 Liverpool | Premier League |
| 13 | Sat 20 Nov 2021 | 10-1 v Wolverhampton WanderersWolverhampton Wanderers 1-0 West Ham United | Premier League |
| 14 | Sun 28 Nov 2021 | 11-2 v Manchester CityManchester City 2-1 West Ham United | Premier League |
| 15 | Wed 1 Dec 2021 | 11-1 v Brighton & Hove AlbionWest Ham United 1-1 Brighton & Hove Albion | Premier League |
| 16 | Sat 4 Dec 2021 | 13-2 v ChelseaWest Ham United 3-2 Chelsea | Premier League |
| 17 | Sun 12 Dec 2021 | 10-0 v BurnleyBurnley 0-0 West Ham United | Premier League |
| 18 | Wed 15 Dec 2021 | 10-2 v ArsenalArsenal 2-0 West Ham United | Premier League |
| 19 | Sun 26 Dec 2021 | 12-3 v SouthamptonWest Ham United 2-3 Southampton | Premier League |
| 20 | Tue 28 Dec 2021 | 14-1 v WatfordWatford 1-4 West Ham United | Premier League |
| 21 | Sat 1 Jan 2022 | 13-2 v Crystal PalaceCrystal Palace 2-3 West Ham United | Premier League |
| 22 | Wed 12 Jan 2022 | 12-0 v Norwich CityWest Ham United 2-0 Norwich City | Premier League |
| 23 | Sun 16 Jan 2022 | 12-3 v Leeds UnitedWest Ham United 2-3 Leeds United | Premier League |
| 24 | Tue 8 Feb 2022 | 11-0 v WatfordWest Ham United 1-0 Watford | Premier League |
| 25 | Sun 13 Feb 2022 | 12-2 v Leicester CityLeicester City 2-2 West Ham United | Premier League |
| 26 | Sat 19 Feb 2022 | 11-1 v Newcastle UnitedWest Ham United 1-1 Newcastle United | Premier League |
| 27 | Sun 27 Feb 2022 | 11-0 v Wolverhampton WanderersWest Ham United 1-0 Wolverhampton Wanderers | Premier League |
| 28 | Sat 5 Mar 2022 | 10-1 v LiverpoolLiverpool 1-0 West Ham United | Premier League |
| 29 | Sun 13 Mar 2022 | 12-1 v Aston VillaWest Ham United 2-1 Aston Villa | Premier League |
| 30 | Sun 20 Mar 2022 | 11-3 v Tottenham HotspurTottenham Hotspur 3-1 West Ham United | Premier League |
| 31 | Sun 3 Apr 2022 | 12-1 v EvertonWest Ham United 2-1 Everton | Premier League |
| 32 | Sun 10 Apr 2022 | 10-2 v BrentfordBrentford 2-0 West Ham United | Premier League |
| 33 | Sun 17 Apr 2022 | 1 1-1 v BurnleyWest Ham United 1-1 Burnley | Premier League |
| 34 | Sun 24 Apr 2022 | 10-1 v ChelseaChelsea 1-0 West Ham United | Premier League |
| 35 | Sun 1 May 2022 | 11-2 v ArsenalWest Ham United 1-2 Arsenal | Premier League |
| 36 | Sun 8 May 2022 | 14-0 v Norwich CityNorwich City 0-4 West Ham United | Premier League |
| 37 | Sun 15 May 2022 | 1 2-2 v Manchester CityWest Ham United 2-2 Manchester City | Premier League |
| 38 | Sun 22 May 2022 | 11-3 v Brighton & Hove AlbionBrighton & Hove Albion 3-1 West Ham United | Premier League |
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