| 1 | Sat 23 Sep | 41-0 v BurnleyBurnley 0-1 Manchester United | Premier League |
| 2 | Tue 26 Sep | 43-0 v Crystal PalaceManchester United 3-0 Crystal Palace | Carabao Cup Third Round |
| 3 | Sat 30 Sep | 4 0-1 v Crystal PalaceManchester United 0-1 Crystal Palace | Premier League |
| 4 | Tue 3 Oct | 42-3 v GalatasarayManchester United 2-3 Galatasaray | UEFA Champions League Group A |
| 5 | Sat 7 Oct | 42-1 v BrentfordManchester United 2-1 Brentford | Premier League |
| 6 | Sat 21 Oct | 42-1 v Sheffield UnitedSheffield United 1-2 Manchester United | Premier League |
| 7 | Tue 24 Oct | 41-0 v FC CopenhagenManchester United 1-0 FC Copenhagen | UEFA Champions League Group A |
| 8 | Sun 29 Oct | 4 0-3 v Manchester CityManchester United 0-3 Manchester City | Premier League |
| 9 | Wed 1 Nov | 4 0-3 v Newcastle UnitedManchester United 0-3 Newcastle United | Carabao Cup Fourth Round |
| 10 | Wed 8 Nov | 43-4 v FC CopenhagenFC Copenhagen 4-3 Manchester United | UEFA Champions League Group A |
| 11 | Sun 26 Nov | 43-0 v EvertonEverton 0-3 Manchester United | Premier League |
| 12 | Wed 29 Nov | 4 3-3 v GalatasarayGalatasaray 3-3 Manchester United | UEFA Champions League Group A |
| 13 | Sat 2 Dec | 40-1 v Newcastle UnitedNewcastle United 1-0 Manchester United | Premier League |
| 14 | Wed 6 Dec | 42-1 v ChelseaManchester United 2-1 Chelsea | Premier League |
| 15 | Sat 9 Dec | 40-3 v AFC BournemouthManchester United 0-3 AFC Bournemouth | Premier League |
| 16 | Tue 12 Dec | 4 0-1 v Bayern MunichManchester United 0-1 Bayern Munich | UEFA Champions League Group A |
| 17 | Sun 17 Dec | 4 0-0 v LiverpoolLiverpool 0-0 Manchester United | Premier League |
| 18 | Wed 17 Jan | 43-0 v TanzaniaMorocco 3-0 Tanzania | Africa Cup of Nations Group F |
| 19 | Sun 21 Jan | 41-1 v DR CongoMorocco 1-1 DR Congo | Africa Cup of Nations Group F |
| 20 | Wed 24 Jan | 41-0 v ZambiaZambia 0-1 Morocco | Africa Cup of Nations Group F |
| 21 | Tue 30 Jan | 4 0-2 v South AfricaMorocco 0-2 South Africa | Africa Cup of Nations Round of 16 |
| 22 | Sun 11 Feb | 42-1 v Aston VillaAston Villa 1-2 Manchester United | Premier League |
| 23 | Sun 18 Feb | 42-1 v Luton TownLuton Town 1-2 Manchester United | Premier League |
| 24 | Wed 28 Feb | 41-0 v Nottingham ForestNottingham Forest 0-1 Manchester United | Emirates FA Cup Fifth Round |
| 25 | Sun 3 Mar | 41-3 v Manchester CityManchester City 3-1 Manchester United | Premier League |
| 26 | Sat 9 Mar | 42-0 v EvertonManchester United 2-0 Everton | Premier League |
| 27 | Fri 22 Mar | 41-0 v AngolaMorocco 1-0 Angola | International Friendly |
| 28 | Sun 7 Apr | 42-2 v LiverpoolManchester United 2-2 Liverpool | Premier League |
| 29 | Wed 24 Apr | 44-2 v Sheffield UnitedManchester United 4-2 Sheffield United | Premier League |
| 30 | Sat 27 Apr | 41-1 v BurnleyManchester United 1-1 Burnley | Premier League |
| 31 | Mon 6 May | 4 0-4 v Crystal PalaceCrystal Palace 4-0 Manchester United | Premier League |
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