| 1 | Sat 7 Aug 2021 | 51-2 v SunderlandSunderland 2-1 Wigan Athletic | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 51-0 v Rotherham UnitedWigan Athletic 1-0 Rotherham United | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 51-1 v Wycombe WanderersWigan Athletic 1-1 Wycombe Wanderers | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 52-0 v Charlton AthleticCharlton Athletic 0-2 Wigan Athletic | Sky Bet League One |
| 5 | Sat 28 Aug 2021 | 5 1-0 v PortsmouthWigan Athletic 1-0 Portsmouth | Sky Bet League One |
| 6 | Sat 11 Sep 2021 | 5 2-1 v Doncaster RoversWigan Athletic 2-1 Doncaster Rovers | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 54-1 v Accrington StanleyAccrington Stanley 1-4 Wigan Athletic | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 52-0 v Cheltenham TownWigan Athletic 2-0 Cheltenham Town | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 5 1-2 v Sheffield WednesdayWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 52-0 v GillinghamGillingham 0-2 Wigan Athletic | Sky Bet League One |
| 11 | Sat 16 Oct 2021 | 54-0 v Bolton WanderersBolton Wanderers 0-4 Wigan Athletic | Sky Bet League One |
| 12 | Tue 19 Oct 2021 | 51-2 v Milton Keynes DonsWigan Athletic 1-2 Milton Keynes Dons | Sky Bet League One |
| 13 | Sat 23 Oct 2021 | 52-0 v AFC WimbledonAFC Wimbledon 0-2 Wigan Athletic | Sky Bet League One |
| 14 | Tue 26 Oct 2021 | 51-2 v Lincoln CityWigan Athletic 1-2 Lincoln City | Sky Bet League One |
| 15 | Sat 30 Oct 2021 | 52-0 v Burton AlbionWigan Athletic 2-0 Burton Albion | Sky Bet League One |
| 16 | Tue 2 Nov 2021 | 53-2 v Fleetwood TownFleetwood Town 2-3 Wigan Athletic | Sky Bet League One |
| 17 | Tue 16 Nov 2021 | 52-1 v Solihull MoorsSolihull Moors 1-2 Wigan Athletic | Emirates FA Cup First Round Replay |
| 18 | Tue 23 Nov 2021 | 52-2 v Cambridge UnitedCambridge United 2-2 Wigan Athletic | Sky Bet League One |
| 19 | Sat 27 Nov 2021 | 52-1 v Plymouth ArgylePlymouth Argyle 1-2 Wigan Athletic | Sky Bet League One |
| 20 | Sun 5 Dec 2021 | 52-1 v Colchester UnitedColchester United 1-2 Wigan Athletic | Emirates FA Cup Second Round |
| 21 | Wed 8 Dec 2021 | 52-1 v Shrewsbury TownWigan Athletic 2-1 Shrewsbury Town | Sky Bet League One |
| 22 | Sat 11 Dec 2021 | 51-1 v Ipswich TownWigan Athletic 1-1 Ipswich Town | Sky Bet League One |
| 23 | Sat 18 Dec 2021 | 5 3-2 v Oxford UnitedOxford United 2-3 Wigan Athletic | Sky Bet League One |
| 24 | Tue 4 Jan 2022 | 56-0 v Oldham AthleticOldham Athletic 0-6 Wigan Athletic | Papa John’s Trophy Third Round |
| 25 | Sat 8 Jan 2022 | 53-2 v Blackburn RoversWigan Athletic 3-2 Blackburn Rovers | Emirates FA Cup Third Round |
| 26 | Sat 15 Jan 2022 | 52-1 v Doncaster RoversDoncaster Rovers 1-2 Wigan Athletic | Sky Bet League One |
| 27 | Tue 18 Jan 2022 | 52-1 v MorecambeMorecambe 1-2 Wigan Athletic | Sky Bet League One |
| 28 | Sat 22 Jan 2022 | 53-2 v GillinghamWigan Athletic 3-2 Gillingham | Sky Bet League One |
| 29 | Sat 29 Jan 2022 | 50-0 v Cheltenham TownCheltenham Town 0-0 Wigan Athletic | Sky Bet League One |
| 30 | Tue 1 Feb 2022 | 51-1 v Oxford UnitedWigan Athletic 1-1 Oxford United | Sky Bet League One |
| 31 | Tue 8 Feb 2022 | 50-1 v Sheffield WednesdaySheffield Wednesday 1-0 Wigan Athletic | Sky Bet League One |
| 32 | Sat 12 Feb 2022 | 52-1 v Charlton AthleticWigan Athletic 2-1 Charlton Athletic | Sky Bet League One |
| 33 | Tue 15 Feb 2022 | 52-0 v Crewe AlexandraWigan Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 34 | Fri 18 Feb 2022 | 51-1 v Rotherham UnitedRotherham United 1-1 Wigan Athletic | Sky Bet League One |
| 35 | Tue 22 Feb 2022 | 53-1 v Wycombe WanderersWycombe Wanderers 1-3 Wigan Athletic | Sky Bet League One |
| 36 | Sat 26 Feb 2022 | 50-3 v SunderlandWigan Athletic 0-3 Sunderland | Sky Bet League One |
| 37 | Tue 1 Mar 2022 | 52-0 v Fleetwood TownWigan Athletic 2-0 Fleetwood Town | Sky Bet League One |
| 38 | Sat 5 Mar 2022 | 51-0 v AFC WimbledonWigan Athletic 1-0 AFC Wimbledon | Sky Bet League One |
| 39 | Sat 12 Mar 2022 | 51-1 v Milton Keynes DonsMilton Keynes Dons 1-1 Wigan Athletic | Sky Bet League One |
| 40 | Tue 15 Mar 2022 | 52-0 v Crewe AlexandraCrewe Alexandra 0-2 Wigan Athletic | Sky Bet League One |
| 41 | Sat 19 Mar 2022 | 54-1 v MorecambeWigan Athletic 4-1 Morecambe | Sky Bet League One |
| 42 | Sat 2 Apr 2022 | 51-1 v Bolton WanderersWigan Athletic 1-1 Bolton Wanderers | Sky Bet League One |
| 43 | Tue 5 Apr 2022 | 53-0 v Accrington StanleyWigan Athletic 3-0 Accrington Stanley | Sky Bet League One |
| 44 | Sat 9 Apr 2022 | 53-1 v Lincoln CityLincoln City 1-3 Wigan Athletic | Sky Bet League One |
| 45 | Tue 12 Apr 2022 | 50-0 v Burton AlbionBurton Albion 0-0 Wigan Athletic | Sky Bet League One |
| 46 | Sat 16 Apr 2022 | 51-2 v Cambridge UnitedWigan Athletic 1-2 Cambridge United | Sky Bet League One |
| 47 | Tue 19 Apr 2022 | 52-2 v Ipswich TownIpswich Town 2-2 Wigan Athletic | Sky Bet League One |
| 48 | Sat 23 Apr 2022 | 51-1 v Plymouth ArgyleWigan Athletic 1-1 Plymouth Argyle | Sky Bet League One |
| 49 | Tue 26 Apr 2022 | 52-3 v PortsmouthPortsmouth 3-2 Wigan Athletic | Sky Bet League One |
| 50 | Sat 30 Apr 2022 | 53-0 v Shrewsbury TownShrewsbury Town 0-3 Wigan Athletic | Sky Bet League One |
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