| 1 | 7/8/2021 | 111-2 v SunderlandSunderland 2-1 Wigan Athletic | Sky Bet League One |
| 2 | 14/8/2021 | 11 1-0 v Rotherham UnitedWigan Athletic 1-0 Rotherham United | Sky Bet League One |
| 3 | 17/8/2021 | 111-1 v Wycombe WanderersWigan Athletic 1-1 Wycombe Wanderers | Sky Bet League One |
| 4 | 21/8/2021 | 112-0 v Charlton AthleticCharlton Athletic 0-2 Wigan Athletic | Sky Bet League One |
| 5 | 24/8/2021 | 110-0 v Bolton WanderersWigan Athletic 0-0 Bolton Wanderers | Carabao Cup Second Round |
| 6 | 28/8/2021 | 111-0 v PortsmouthWigan Athletic 1-0 Portsmouth | Sky Bet League One |
| 7 | 21/9/2021 | 110-2 v SunderlandWigan Athletic 0-2 Sunderland | Carabao Cup Third Round |
| 8 | 25/9/2021 | 112-0 v Cheltenham TownWigan Athletic 2-0 Cheltenham Town | Sky Bet League One |
| 9 | 28/9/2021 | 111-2 v Sheffield WednesdayWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 10 | 2/10/2021 | 11 2-0 v GillinghamGillingham 0-2 Wigan Athletic | Sky Bet League One |
| 11 | 5/10/2021 | 110-2 v Crewe AlexandraCrewe Alexandra 2-0 Wigan Athletic | Checkatrade Trophy |
| 12 | 16/10/2021 | 11 4-0 v Bolton WanderersBolton Wanderers 0-4 Wigan Athletic | Sky Bet League One |
| 13 | 19/10/2021 | 111-2 v Milton Keynes DonsWigan Athletic 1-2 Milton Keynes Dons | Sky Bet League One |
| 14 | 23/10/2021 | 112-0 v AFC WimbledonAFC Wimbledon 0-2 Wigan Athletic | Sky Bet League One |
| 15 | 26/10/2021 | 111-2 v Lincoln CityWigan Athletic 1-2 Lincoln City | Sky Bet League One |
| 16 | 30/10/2021 | 112-0 v Burton AlbionWigan Athletic 2-0 Burton Albion | Sky Bet League One |
| 17 | 2/11/2021 | 113-2 v Fleetwood TownFleetwood Town 2-3 Wigan Athletic | Sky Bet League One |
| 18 | 10/11/2021 | 112-0 v Shrewsbury TownWigan Athletic 2-0 Shrewsbury Town | Checkatrade Trophy |
| 19 | 16/11/2021 | 112-1 v Solihull MoorsSolihull Moors 1-2 Wigan Athletic | Emirates FA Cup |
| 20 | 23/11/2021 | 112-2 v Cambridge UnitedCambridge United 2-2 Wigan Athletic | Sky Bet League One |
| 21 | 27/11/2021 | 112-1 v Plymouth ArgylePlymouth Argyle 1-2 Wigan Athletic | Sky Bet League One |
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