| 1 | Sun 22 Aug 2021 | 30-1 v Tottenham HotspurWolverhampton Wanderers 0-1 Tottenham Hotspur | Premier League |
| 2 | Tue 24 Aug 2021 | 34-0 v Nottingham ForestNottingham Forest 0-4 Wolverhampton Wanderers | Carabao Cup Second Round |
| 3 | Wed 22 Sep 2021 | 32-2 v Tottenham HotspurWolverhampton Wanderers 2-2 Tottenham Hotspur | Carabao Cup Third Round |
| 4 | Sat 23 Oct 2021 | 31-1 v Leeds UnitedLeeds United 1-1 Wolverhampton Wanderers | Premier League |
| 5 | Mon 1 Nov 2021 | 3 2-1 v EvertonWolverhampton Wanderers 2-1 Everton | Premier League |
| 6 | Sat 6 Nov 2021 | 30-2 v Crystal PalaceCrystal Palace 2-0 Wolverhampton Wanderers | Premier League |
| 7 | Sat 20 Nov 2021 | 31-0 v West Ham UnitedWolverhampton Wanderers 1-0 West Ham United | Premier League |
| 8 | Sat 27 Nov 2021 | 30-0 v Norwich CityNorwich City 0-0 Wolverhampton Wanderers | Premier League |
| 9 | Wed 1 Dec 2021 | 30-0 v BurnleyWolverhampton Wanderers 0-0 Burnley | Premier League |
| 10 | Sat 4 Dec 2021 | 30-1 v LiverpoolWolverhampton Wanderers 0-1 Liverpool | Premier League |
| 11 | Sat 11 Dec 2021 | 30-1 v Manchester CityManchester City 1-0 Wolverhampton Wanderers | Premier League |
| 12 | Wed 15 Dec 2021 | 31-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-1 Wolverhampton Wanderers | Premier League |
| 13 | Sun 9 Jan 2022 | 33-0 v Sheffield UnitedWolverhampton Wanderers 3-0 Sheffield United | Emirates FA Cup Third Round |
| 14 | Sat 15 Jan 2022 | 33-1 v SouthamptonWolverhampton Wanderers 3-1 Southampton | Premier League |
| 15 | Sat 22 Jan 2022 | 32-1 v BrentfordBrentford 1-2 Wolverhampton Wanderers | Premier League |
| 16 | Sat 5 Feb 2022 | 30-1 v Norwich CityWolverhampton Wanderers 0-1 Norwich City | Emirates FA Cup Fourth Round |
| 17 | Thu 10 Feb 2022 | 30-1 v ArsenalWolverhampton Wanderers 0-1 Arsenal | Premier League |
| 18 | Sun 13 Feb 2022 | 3 2-0 v Tottenham HotspurTottenham Hotspur 0-2 Wolverhampton Wanderers | Premier League |
| 19 | Sun 20 Feb 2022 | 3 2-1 v Leicester CityWolverhampton Wanderers 2-1 Leicester City | Premier League |
| 20 | Thu 24 Feb 2022 | 31-2 v ArsenalArsenal 2-1 Wolverhampton Wanderers | Premier League |
| 21 | Thu 10 Mar 2022 | 3 4-0 v WatfordWolverhampton Wanderers 4-0 Watford | Premier League |
| 22 | Fri 18 Mar 2022 | 32-3 v Leeds UnitedWolverhampton Wanderers 2-3 Leeds United | Premier League |
| 23 | Fri 8 Apr 2022 | 30-1 v Newcastle UnitedNewcastle United 1-0 Wolverhampton Wanderers | Premier League |
| 24 | Sat 30 Apr 2022 | 30-3 v Brighton & Hove AlbionWolverhampton Wanderers 0-3 Brighton & Hove Albion | Premier League |
| 25 | Sat 7 May 2022 | 32-2 v ChelseaChelsea 2-2 Wolverhampton Wanderers | Premier League |
| 26 | Wed 11 May 2022 | 31-5 v Manchester CityWolverhampton Wanderers 1-5 Manchester City | Premier League |
| 27 | Sun 15 May 2022 | 31-1 v Norwich CityWolverhampton Wanderers 1-1 Norwich City | Premier League |
| 28 | Sun 22 May 2022 | 31-3 v LiverpoolLiverpool 3-1 Wolverhampton Wanderers | Premier League |
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