| 1 | Sat 12 Aug | 33 1-1 v AFC BournemouthAFC Bournemouth 1-1 West Ham United | Premier League |
| 2 | Sun 20 Aug | 33 3-1 v ChelseaWest Ham United 3-1 Chelsea | Premier League |
| 3 | Sat 26 Aug | 333-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-3 West Ham United | Premier League |
| 4 | Fri 1 Sep | 33 2-1 v Luton TownLuton Town 1-2 West Ham United | Premier League |
| 5 | Sat 16 Sep | 331-3 v Manchester CityWest Ham United 1-3 Manchester City | Premier League |
| 6 | Thu 21 Sep | 333-1 v Backa TopolaWest Ham United 3-1 Backa Topola | UEFA Europa League Group A |
| 7 | Sun 24 Sep | 331-3 v LiverpoolLiverpool 3-1 West Ham United | Premier League |
| 8 | Sat 30 Sep | 332-0 v Sheffield UnitedWest Ham United 2-0 Sheffield United | Premier League |
| 9 | Thu 5 Oct | 332-1 v SC FreiburgSC Freiburg 1-2 West Ham United | UEFA Europa League Group A |
| 10 | Sun 8 Oct | 33 2-2 v Newcastle UnitedWest Ham United 2-2 Newcastle United | Premier League |
| 11 | Sun 22 Oct | 33 1-4 v Aston VillaAston Villa 4-1 West Ham United | Premier League |
| 12 | Thu 26 Oct | 33 1-2 v OlympiakosOlympiakos 2-1 West Ham United | UEFA Europa League Group A |
| 13 | Wed 1 Nov | 333-1 v ArsenalWest Ham United 3-1 Arsenal | Carabao Cup Fourth Round |
| 14 | Sat 4 Nov | 33 2-3 v BrentfordBrentford 3-2 West Ham United | Premier League |
| 15 | Thu 9 Nov | 331-0 v OlympiakosWest Ham United 1-0 Olympiakos | UEFA Europa League Group A |
| 16 | Sun 12 Nov | 333-2 v Nottingham ForestWest Ham United 3-2 Nottingham Forest | Premier League |
| 17 | Sat 25 Nov | 332-1 v BurnleyBurnley 1-2 West Ham United | Premier League |
| 18 | Thu 30 Nov | 33 1-0 v Backa TopolaBacka Topola 0-1 West Ham United | UEFA Europa League Group A |
| 19 | Sun 3 Dec | 331-1 v Crystal PalaceWest Ham United 1-1 Crystal Palace | Premier League |
| 20 | Thu 7 Dec | 33 2-1 v Tottenham HotspurTottenham Hotspur 1-2 West Ham United | Premier League |
| 21 | Sun 10 Dec | 330-5 v FulhamFulham 5-0 West Ham United | Premier League |
| 22 | Thu 14 Dec | 332-0 v SC FreiburgWest Ham United 2-0 SC Freiburg | UEFA Europa League Group A |
| 23 | Sun 17 Dec | 333-0 v Wolverhampton WanderersWest Ham United 3-0 Wolverhampton Wanderers | Premier League |
| 24 | Sat 23 Dec | 332-0 v Manchester UnitedWest Ham United 2-0 Manchester United | Premier League |
| 25 | Thu 28 Dec | 332-0 v ArsenalArsenal 0-2 West Ham United | Premier League |
| 26 | Tue 2 Jan | 330-0 v Brighton & Hove AlbionWest Ham United 0-0 Brighton & Hove Albion | Premier League |
| 27 | Sun 7 Jan | 331-1 v Bristol CityWest Ham United 1-1 Bristol City | Emirates FA Cup Third Round |
| 28 | Tue 16 Jan | 330-1 v Bristol CityBristol City 1-0 West Ham United | Emirates FA Cup Third Round Replay |
| 29 | Sun 21 Jan | 332-2 v Sheffield UnitedSheffield United 2-2 West Ham United | Premier League |
| 30 | Thu 1 Feb | 331-1 v AFC BournemouthWest Ham United 1-1 AFC Bournemouth | Premier League |
| 31 | Sun 4 Feb | 330-3 v Manchester UnitedManchester United 3-0 West Ham United | Premier League |
| 32 | Sun 11 Feb | 330-6 v ArsenalWest Ham United 0-6 Arsenal | Premier League |
| 33 | Sat 17 Feb | 330-2 v Nottingham ForestNottingham Forest 2-0 West Ham United | Premier League |
| 34 | Mon 26 Feb | 334-2 v BrentfordWest Ham United 4-2 Brentford | Premier League |
| 35 | Sat 2 Mar | 333-1 v EvertonEverton 1-3 West Ham United | Premier League |
| 36 | Thu 7 Mar | 330-1 v SC FreiburgSC Freiburg 1-0 West Ham United | UEFA Europa League Round of 16 |
| 37 | Sun 17 Mar | 331-1 v Aston VillaWest Ham United 1-1 Aston Villa | Premier League |
| 38 | Sat 30 Mar | 333-4 v Newcastle UnitedNewcastle United 4-3 West Ham United | Premier League |
| 39 | Tue 2 Apr | 331-1 v Tottenham HotspurWest Ham United 1-1 Tottenham Hotspur | Premier League |
| 40 | Sat 6 Apr | 33 2-1 v Wolverhampton WanderersWolverhampton Wanderers 1-2 West Ham United | Premier League |
| 41 | Thu 11 Apr | 33 0-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-0 West Ham United | UEFA Europa League Quarter Final |
| 42 | Sun 14 Apr | 330-2 v FulhamWest Ham United 0-2 Fulham | Premier League |
| 43 | Sun 21 Apr | 332-5 v Crystal PalaceCrystal Palace 5-2 West Ham United | Premier League |
| 44 | Sat 27 Apr | 332-2 v LiverpoolWest Ham United 2-2 Liverpool | Premier League |
| 45 | Sun 5 May | 33 0-5 v ChelseaChelsea 5-0 West Ham United | Premier League |
| 46 | Sat 11 May | 33 3-1 v Luton TownWest Ham United 3-1 Luton Town | Premier League |
| 47 | Sun 19 May | 331-3 v Manchester CityManchester City 3-1 West Ham United | Premier League |
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