| 1 | Sun 6 Sep 2020 | 21-1 v BrentfordBrentford 1-1 Wycombe Wanderers | Carabao Cup First Round |
| 2 | Sat 12 Sep 2020 | 20-1 v Rotherham UnitedWycombe Wanderers 0-1 Rotherham United | Sky Bet Championship |
| 3 | Sat 19 Sep 2020 | 20-5 v Blackburn RoversBlackburn Rovers 5-0 Wycombe Wanderers | Sky Bet Championship |
| 4 | Sat 26 Sep 2020 | 20-2 v Swansea CityWycombe Wanderers 0-2 Swansea City | Sky Bet Championship |
| 5 | Sat 3 Oct 2020 | 20-2 v Luton TownLuton Town 2-0 Wycombe Wanderers | Sky Bet Championship |
| 6 | Sat 17 Oct 2020 | 21-2 v MillwallWycombe Wanderers 1-2 Millwall | Sky Bet Championship |
| 7 | Tue 20 Oct 2020 | 20-1 v ReadingReading 1-0 Wycombe Wanderers | Sky Bet Championship |
| 8 | Sat 24 Oct 2020 | 21-2 v Norwich CityNorwich City 2-1 Wycombe Wanderers | Sky Bet Championship |
| 9 | Tue 27 Oct 2020 | 21-1 v WatfordWycombe Wanderers 1-1 Watford | Sky Bet Championship |
| 10 | Sat 31 Oct 2020 | 21-0 v Sheffield WednesdayWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet Championship |
| 11 | Wed 4 Nov 2020 | 22-1 v Birmingham CityBirmingham City 1-2 Wycombe Wanderers | Sky Bet Championship |
| 12 | Sat 7 Nov 2020 | 2 0-2 v Nottingham ForestNottingham Forest 2-0 Wycombe Wanderers | Sky Bet Championship |
| 13 | Sat 21 Nov 2020 | 20-0 v BrentfordWycombe Wanderers 0-0 Brentford | Sky Bet Championship |
| 14 | Tue 24 Nov 2020 | 20-0 v Huddersfield TownWycombe Wanderers 0-0 Huddersfield Town | Sky Bet Championship |
| 15 | Sat 28 Nov 2020 | 21-1 v Derby CountyDerby County 1-1 Wycombe Wanderers | Sky Bet Championship |
| 16 | Wed 2 Dec 2020 | 20-1 v Stoke CityWycombe Wanderers 0-1 Stoke City | Sky Bet Championship |
| 17 | Sat 5 Dec 2020 | 2 2-2 v Preston North EndPreston North End 2-2 Wycombe Wanderers | Sky Bet Championship |
| 18 | Wed 9 Dec 2020 | 2 1-2 v BarnsleyBarnsley 2-1 Wycombe Wanderers | Sky Bet Championship |
| 19 | Sat 12 Dec 2020 | 21-2 v Coventry CityWycombe Wanderers 1-2 Coventry City | Sky Bet Championship |
| 20 | Tue 15 Dec 2020 | 20-1 v AFC BournemouthAFC Bournemouth 1-0 Wycombe Wanderers | Sky Bet Championship |
| 21 | Sat 19 Dec 2020 | 21-1 v Queens Park RangersWycombe Wanderers 1-1 Queens Park Rangers | Sky Bet Championship |
| 22 | Sat 26 Dec 2020 | 21-2 v Bristol CityBristol City 2-1 Wycombe Wanderers | Sky Bet Championship |
| 23 | Tue 29 Dec 2020 | 22-1 v Cardiff CityWycombe Wanderers 2-1 Cardiff City | Sky Bet Championship |
| 24 | Sat 2 Jan 2021 | 21-3 v MiddlesbroughWycombe Wanderers 1-3 Middlesbrough | Sky Bet Championship |
| 25 | Mon 25 Jan 2021 | 21-4 v Tottenham HotspurWycombe Wanderers 1-4 Tottenham Hotspur | Emirates FA Cup Fourth Round |
| 26 | Sat 30 Jan 2021 | 22-7 v BrentfordBrentford 7-2 Wycombe Wanderers | Sky Bet Championship |
| 27 | Tue 2 Feb 2021 | 2 0-0 v Birmingham CityWycombe Wanderers 0-0 Birmingham City | Sky Bet Championship |
| 28 | Sat 6 Feb 2021 | 20-3 v Nottingham ForestWycombe Wanderers 0-3 Nottingham Forest | Sky Bet Championship |
| 29 | Sat 13 Feb 2021 | 2 3-2 v Huddersfield TownHuddersfield Town 2-3 Wycombe Wanderers | Sky Bet Championship |
| 30 | Tue 16 Feb 2021 | 21-2 v Derby CountyWycombe Wanderers 1-2 Derby County | Sky Bet Championship |
| 31 | Sat 20 Feb 2021 | 20-0 v MillwallMillwall 0-0 Wycombe Wanderers | Sky Bet Championship |
| 32 | Tue 23 Feb 2021 | 21-0 v ReadingWycombe Wanderers 1-0 Reading | Sky Bet Championship |
| 33 | Sun 28 Feb 2021 | 20-2 v Norwich CityWycombe Wanderers 0-2 Norwich City | Sky Bet Championship |
| 34 | Wed 3 Mar 2021 | 20-2 v WatfordWatford 2-0 Wycombe Wanderers | Sky Bet Championship |
| 35 | Sat 13 Mar 2021 | 21-0 v Preston North EndWycombe Wanderers 1-0 Preston North End | Sky Bet Championship |
| 36 | Fri 2 Apr 2021 | 21-0 v Blackburn RoversWycombe Wanderers 1-0 Blackburn Rovers | Sky Bet Championship |
| 37 | Mon 5 Apr 2021 | 23-0 v Rotherham UnitedRotherham United 0-3 Wycombe Wanderers | Sky Bet Championship |
| 38 | Sat 10 Apr 2021 | 21-3 v Luton TownWycombe Wanderers 1-3 Luton Town | Sky Bet Championship |
| 39 | Sat 17 Apr 2021 | 22-2 v Swansea CitySwansea City 2-2 Wycombe Wanderers | Sky Bet Championship |
| 40 | Wed 21 Apr 2021 | 22-1 v Bristol CityWycombe Wanderers 2-1 Bristol City | Sky Bet Championship |
| 41 | Sat 24 Apr 2021 | 21-2 v Cardiff CityCardiff City 2-1 Wycombe Wanderers | Sky Bet Championship |
| 42 | Sat 1 May 2021 | 21-0 v AFC BournemouthWycombe Wanderers 1-0 AFC Bournemouth | Sky Bet Championship |
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