| 1 | Tue 10 Aug 2021 | 160-0 v Exeter CityExeter City 0-0 Wycombe Wanderers | Carabao Cup First Round |
| 2 | Sat 14 Aug 2021 | 163-1 v Cheltenham TownCheltenham Town 1-3 Wycombe Wanderers | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 161-1 v Wigan AthleticWigan Athletic 1-1 Wycombe Wanderers | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 161-0 v Lincoln CityWycombe Wanderers 1-0 Lincoln City | Sky Bet League One |
| 5 | Tue 24 Aug 2021 | 162-2 v StevenageStevenage 2-2 Wycombe Wanderers | Carabao Cup Second Round |
| 6 | Sat 28 Aug 2021 | 161-3 v SunderlandSunderland 3-1 Wycombe Wanderers | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 162-1 v Charlton AthleticWycombe Wanderers 2-1 Charlton Athletic | Sky Bet League One |
| 8 | Tue 21 Sep 2021 | 161-6 v Manchester CityManchester City 6-1 Wycombe Wanderers | Carabao Cup Third Round |
| 9 | Tue 28 Sep 2021 | 16 2-1 v Shrewsbury TownShrewsbury Town 1-2 Wycombe Wanderers | Sky Bet League One |
| 10 | Tue 19 Oct 2021 | 160-0 v Rotherham UnitedRotherham United 0-0 Wycombe Wanderers | Sky Bet League One |
| 11 | Sat 23 Oct 2021 | 162-1 v Crewe AlexandraWycombe Wanderers 2-1 Crewe Alexandra | Sky Bet League One |
| 12 | Tue 2 Nov 2021 | 161-4 v Ipswich TownWycombe Wanderers 1-4 Ipswich Town | Sky Bet League One |
| 13 | Sat 6 Nov 2021 | 162-2 v Hartlepool UnitedHartlepool United 2-2 Wycombe Wanderers | Emirates FA Cup First Round |
| 14 | Sat 20 Nov 2021 | 161-0 v Bolton WanderersWycombe Wanderers 1-0 Bolton Wanderers | Sky Bet League One |
| 15 | Sat 27 Nov 2021 | 162-2 v Sheffield WednesdaySheffield Wednesday 2-2 Wycombe Wanderers | Sky Bet League One |
| 16 | Sat 11 Dec 2021 | 162-2 v AFC WimbledonWycombe Wanderers 2-2 AFC Wimbledon | Sky Bet League One |
| 17 | Tue 8 Feb 2022 | 160-0 v Shrewsbury TownWycombe Wanderers 0-0 Shrewsbury Town | Sky Bet League One |
| 18 | Sat 19 Feb 2022 | 165-5 v Cheltenham TownWycombe Wanderers 5-5 Cheltenham Town | Sky Bet League One |
| 19 | Tue 22 Feb 2022 | 161-3 v Wigan AthleticWycombe Wanderers 1-3 Wigan Athletic | Sky Bet League One |
| 20 | Sat 26 Feb 2022 | 162-3 v Accrington StanleyAccrington Stanley 3-2 Wycombe Wanderers | Sky Bet League One |
| 21 | Mon 18 Apr 2022 | 161-1 v AFC WimbledonAFC Wimbledon 1-1 Wycombe Wanderers | Sky Bet League One |
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