| 1 | 7/8/2021 | 52-1 v Accrington StanleyWycombe Wanderers 2-1 Accrington Stanley | Sky Bet League One |
| 2 | 10/8/2021 | 50-0 v Exeter CityExeter City 0-0 Wycombe Wanderers | Carabao Cup First Round |
| 3 | 14/8/2021 | 53-1 v Cheltenham TownCheltenham Town 1-3 Wycombe Wanderers | Sky Bet League One |
| 4 | 17/8/2021 | 51-1 v Wigan AthleticWigan Athletic 1-1 Wycombe Wanderers | Sky Bet League One |
| 5 | 21/8/2021 | 51-0 v Lincoln CityWycombe Wanderers 1-0 Lincoln City | Sky Bet League One |
| 6 | 24/8/2021 | 52-2 v StevenageStevenage 2-2 Wycombe Wanderers | Carabao Cup Second Round |
| 7 | 11/9/2021 | 50-0 v Oxford UnitedOxford United 0-0 Wycombe Wanderers | Sky Bet League One |
| 8 | 18/9/2021 | 52-1 v Charlton AthleticWycombe Wanderers 2-1 Charlton Athletic | Sky Bet League One |
| 9 | 21/9/2021 | 51-6 v Manchester CityManchester City 6-1 Wycombe Wanderers | Carabao Cup Third Round |
| 10 | 25/9/2021 | 5 0-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Wycombe Wanderers | Sky Bet League One |
| 11 | 28/9/2021 | 5 2-1 v Shrewsbury TownShrewsbury Town 1-2 Wycombe Wanderers | Sky Bet League One |
| 12 | 2/10/2021 | 54-3 v MorecambeWycombe Wanderers 4-3 Morecambe | Sky Bet League One |
| 13 | 5/10/2021 | 51-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Wycombe Wanderers | Checkatrade Trophy |
| 14 | 9/10/2021 | 52-0 v GillinghamWycombe Wanderers 2-0 Gillingham | Sky Bet League One |
| 15 | 16/10/2021 | 52-0 v Doncaster RoversDoncaster Rovers 0-2 Wycombe Wanderers | Sky Bet League One |
| 16 | 19/10/2021 | 50-0 v Rotherham UnitedRotherham United 0-0 Wycombe Wanderers | Sky Bet League One |
| 17 | 23/10/2021 | 52-1 v Crewe AlexandraWycombe Wanderers 2-1 Crewe Alexandra | Sky Bet League One |
| 18 | 30/10/2021 | 53-3 v Fleetwood TownFleetwood Town 3-3 Wycombe Wanderers | Sky Bet League One |
| 19 | 2/11/2021 | 51-4 v Ipswich TownWycombe Wanderers 1-4 Ipswich Town | Sky Bet League One |
| 20 | 13/11/2021 | 50-1 v PortsmouthWycombe Wanderers 0-1 Portsmouth | Sky Bet League One |
| 21 | 16/11/2021 | 5 0-1 v Hartlepool UnitedWycombe Wanderers 0-1 Hartlepool United | Emirates FA Cup First Round Replay |
| 22 | 20/11/2021 | 51-0 v Bolton WanderersWycombe Wanderers 1-0 Bolton Wanderers | Sky Bet League One |
| 23 | 23/11/2021 | 5 3-0 v Plymouth ArgylePlymouth Argyle 0-3 Wycombe Wanderers | Sky Bet League One |
| 24 | 27/11/2021 | 5 2-2 v Sheffield WednesdaySheffield Wednesday 2-2 Wycombe Wanderers | Sky Bet League One |
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